Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice

doi:10.1002/ptr.7901

科研成果详情

题名	Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice
作者	Lin, Zhiyong1; Wang, Fengwei 2; Yan, Yawei3; Jin, Jiabao3; Quan, Zijiao 4; Tong, Haibin 4; Du, Jie 1,5
发表日期	2023-09
发表期刊	PHYTOTHERAPY RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	diabetes fucoidan inflammation oxidative stress Sargassum pallidum
其他关键词	MOLECULAR-WEIGHT FUCOIDAN ; CARDIOMYOPATHY ; MELLITUS ; MODELS
摘要	Type 2 diabetes mellitus (T2DM) and its complications have become a serious global health epidemic. Cardiovascular complications have considered as a major cause of high mortality in diabetic patients. Fucoidans from brown algae have diverse medicinal activities, however, few studies reported pharmacological activity of Sargassum. pallidum fucoidan (Sp-Fuc). Therefore, the aim of this study was to investigate the effects of Sp-Fuc on diabetic symptoms and cardiac injury in spontaneous diabetic db/db mice. SP-Fuc at 200 mg/(kg/d) was administered intragastrically to db/db mice for 8 weeks, the effects on hyperlipidemia, hyperglycemia, insulin resistance, and cardiac damage, as well as oxidative stress, inflammation, Nrf2/ARE, and NF-kappa B signaling pathways, were investigated. Our data demonstrated that Sp-Fuc significantly (p < 0.05) decreased body weights, hyperlipidemia, and hyperglycemia in db/db mice, along with improved insulin sensitivity. Additionally, Sp-Fuc significantly (p < 0.05) alleviated cardiac dysfunction and pathological morphology of cardiac tissue. Sp-Fuc also significantly (p < 0.05) decreased lipid peroxidation, increased antioxidant function, as well as reduced cardiac inflammation, possibly through Nrf2/ARE and NF-kappa B signaling. Sp-Fuc can ameliorate the metabolism disorders of glucose and lipid in diabetic mice by activating Nrf2/ARE antioxidant signaling, simultaneously reducing cardiac redox imbalance and inflammatory damage. The present findings provide a perspective on the therapy strategy for T2DM and its complications.
资助项目	National Natural Science Foundation of China[81872952];Science and Technology Program of Wenzhou[ZY2021010]
出版者	WILEY
ISSN	0951-418X
EISSN	1099-1573
卷号	37 期号:9 页码:4210-4223
DOI	10.1002/ptr.7901
页数	14
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000997089800001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-05
URL	查看原文
PubMed ID	3725336
SCOPUSEID	2-s2.0-85161328892
通讯作者地址	[Du, Jie]Department of Cardiovascular and Thoracic Surgery,The Second Affiliated Hospital,Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Tong, Haibin]Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection,College of Life and Environmental Science,Wenzhou University,Wenzhou,325035,China
Scopus学科分类	Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180100
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院药学院（分析测试中心）_生物制药系其他_附属第三医院（瑞安市人民医院）
通讯作者	Tong, Haibin; Du, Jie
作者单位	1.Department of Cardiovascular and Thoracic Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.Pharmaceutical Department,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Biopharmaceuticals,College of Pharmacy,Wenzhou Medical University,Wenzhou,China; 4.Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection,Department of Biopharmaceuticals,College of Life and Environmental Science,Wenzhou University,Wenzhou,China; 5.Department of Surgery,The Second People's Hospital of Pingyang County,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Lin, Zhiyong,Wang, Fengwei,Yan, Yawei,et al. Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice[J]. PHYTOTHERAPY RESEARCH,2023,37(9):4210-4223.
APA	Lin, Zhiyong., Wang, Fengwei., Yan, Yawei., Jin, Jiabao., Quan, Zijiao., ... & Du, Jie. (2023). Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice. PHYTOTHERAPY RESEARCH, 37(9), 4210-4223.
MLA	Lin, Zhiyong,et al."Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice".PHYTOTHERAPY RESEARCH 37.9(2023):4210-4223.