Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease

doi:10.3389/fcimb.2023.1157368

科研成果详情

题名	Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease
作者	Niu, Chenguang 1,2,3,4,5; Tu, Ye 1,2,3,4,5; Jin, Qiaoqiao 1,2,3,4,5; Chen, Zhanyi 1,2,3,4,5; Yuan, Keyong 1,2,3,4,5; Wang, Min 6,7; Zhang, Pengfei 1,2,3,4,5; Luo, Junyuan 1,2,3,4,5; Li, Hao 1,2,3,4,5; Yang, Yueyi 1,2,3,4,5; Liu, Xiaoyu 1,2,3,4,5; Mao, Mengying 1,2,3,4,5; Dong, Ting 1,2,3,4,5; Tan, Wenduo 1,2,3,4,5; Hu, Xuchen 1,2,3,4,5; Pan, Yihuai6,7; Hou, Lili 8; Ma, Rui 1,2,3,4,5; Huang, Zhengwei 1,2,3,4,5
发表日期	2023-04-26
发表期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	metabolic dysfunction-associated fatty liver disease oral mycobiome gut mycobiome oral-gut axis metagenomics
摘要	Metabolic dysfunction-associated fatty liver disease (MAFLD) is a phenotype of liver diseases associated with metabolic syndrome. The pathogenesis MAFLD remains unclear. The liver maintains is located near the intestine and is physiologically interdependent with the intestine via metabolic exchange and microbial transmission, underpinning the recently proposed oral-gut-liver axis concept. However, little is known about the roles of commensal fungi in the disease development. This study aimed to characterize the alterations of oral and gut mycobiota and their roles in MAFLD. Twenty-one MAFLD participants and 20 healthy controls were enrolled. Metagenomics analyses of saliva, supragingival plaques, and feces revealed significant alterations in the gut fungal composition of MAFLD patients. Although no statistical difference was evident in the oral mycobiome diversity within MAFLD and healthy group, significantly decreased diversities were observed in fecal samples of MAFLD patients. The relative abundance of one salivary species, five supragingival species, and seven fecal species was significantly altered in MAFLD patients. Twenty-two salivary, 23 supragingival, and 22 fecal species were associated with clinical parameters. Concerning the different functions of fungal species, pathways involved in metabolic pathways, biosynthesis of secondary metabolites, microbial metabolism in diverse environments, and carbon metabolism were abundant both in the oral and gut mycobiomes. Moreover, different fungal contributions in core functions were observed between MAFLD patients and the healthy controls, especially in the supragingival plaque and fecal samples. Finally, correlation analysis between oral/gut mycobiome and clinical parameters identified correlations of certain fungal species in both oral and gut niches. Particularly, Mucor ambiguus, which was abundant both in saliva and feces, was positively correlated with body mass index, total cholesterol, low-density lipoprotein, alanine aminotransferase, and aspartate aminotransferase, providing evidence of a possible oral-gut-liver axis. The findings illustrate the potential correlation between core mycobiome and the development of MAFLD and could propose potential therapeutic strategies.
资助项目	Clinical Research Plan of SHDC[SHDC2020CR5015];Shanghai Pujiang Program[2021PJD034];School of Medicine[JYJC202223/KQYJXK2020];National Natural Science Foundation of China[82071104/81570964];Science and Technology Commission of Shanghai Municipality[22Y21901000];Shanghai Hospital Development Center[19MC1910600,NCRCO2021-omics-07,SHDC12022120];
出版者	FRONTIERS MEDIA SA
ISSN	2235-2988
卷号	13
DOI	10.3389/fcimb.2023.1157368
页数	12
WOS类目	Immunology ; Microbiology
WOS研究方向	Immunology ; Microbiology
WOS记录号	WOS:000984964800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37180439
SCOPUSEID	2-s2.0-85159144763
通讯作者地址	[Ma, Rui]Department of Endodontics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China ; [Huang, Zhengwei]Department of Endodontics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Scopus学科分类	Microbiology;Immunology;Microbiology (medical);Infectious Diseases
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180061
专题	口腔医学院、附属口腔医院_口腔医学研究所口腔医学院、附属口腔医院
通讯作者	Ma, Rui; Huang, Zhengwei
作者单位	1.Department of Endodontics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 2.College of Stomatology,Shanghai Jiao Tong University,Shanghai,China; 3.National Clinical Research Center for Oral Diseases,Shanghai,China; 4.National Center for Stomatology,Shanghai,China; 5.Shanghai Key Laboratory of Stomatology,Shanghai,China; 6.Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 7.Department of Endodontics,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 8.Department of Nursing,Shanghai Ninth People’s Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,China
推荐引用方式 GB/T 7714	Niu, Chenguang,Tu, Ye,Jin, Qiaoqiao,et al. Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2023,13.
APA	Niu, Chenguang., Tu, Ye., Jin, Qiaoqiao., Chen, Zhanyi., Yuan, Keyong., ... & Huang, Zhengwei. (2023). Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 13.
MLA	Niu, Chenguang,et al."Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 13(2023).