Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer Analysis from a Large-Scale Cohort

doi:10.1097/MD.0000000000003164

科研成果详情

题名	Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer Analysis from a Large-Scale Cohort
作者	Zhuang, Cheng-Le 1; Huang, Dong-Dong 1; Pang, Wen-Yang1; Zhou, Chong-Jun 1; Wang, Su-Lin1; Lou, Neng1; Ma, Liang-Liang1; Yu, Zhen 1,2; Shen, Xian1
发表日期	2016-03
发表期刊	MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	OBESITY SKELETAL-MUSCLE ; COLORECTAL-CANCER ; NUTRITIONAL ASSESSMENT ; CLINICAL-IMPLICATIONS ; PROGNOSTIC-FACTOR ; BODY-COMPOSITION ; RESECTION ; SURGERY ; OUTCOMES ; ADENOCARCINOMA
摘要	Currently, the association between sarcopenia and long-term prognosis after gastric cancer surgery has not been investigated. Moreover, the association between sarcopenia and postoperative complications remains controversial. This large-scale retrospective study aims to ascertain the prevalence of sarcopenia and assess its impact on postoperative complications and long-term survival in patients undergoing radical gastrectomy for gastric cancer. From December 2008 to April 2013, the clinical data of all patients who underwent elective radical gastrectomy for gastric cancer were collected prospectively. Only patients with available preoperative abdominal CT scan within 30 days of surgery were considered for analysis. Skeletal muscle mass was determined by abdominal (computed tomography) CT scan, and sarcopenia was diagnosed by the cut-off values obtained by means of optimum stratification. Univariate and multivariate analyses evaluating risk factors of postoperative complications and long-term survival were performed. A total of 937 patients were included in this study, and 389 (41.5%) patients were sarcopenic based on the diagnostic cut-off values (34.9 cm(2)/m(2) for women and 40.8 cm(2)/m(2) for men). Sarcopenia was an independent risk factor for severe postoperative complications (OR=3.010, P < 0.001), but not for total complications. However, sarcopenia did not show significant association with operative mortality. Moreover, sarcopenia was an independent predictor for poorer overall survival (HR=1.653, P < 0.001) and disease-free survival (HR=1.620, P < 0.001). Under the adjusted tumor-node-metastasis (TNM) stage, sarcopenia remained an independent risk factor for overall survival and disease-free survival in patients with TNM stage II and III, but not in patients with TNM stage I. Sarcopenia is an independent predictive factor of severe postoperative complications after radical gastrectomy for gastric cancer. Moreover, sarcopenia is independently associated with overall and disease-free survival in patients with TNM stage II and III, but not in patients with TNM stage I.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171857]; clinical nutriology of medical supporting discipline of Zhejiang Province [11-ZC24]
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0025-7974
EISSN	1536-5964
卷号	95 期号:13 页码:e3164.
DOI	10.1097/MD.0000000000003164
页数	10
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000375256500011
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27043677
PMC记录号	PMC4998538
SCOPUSEID	2-s2.0-84962777616
ESI高被引论文	2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 ; 2024-11
通讯作者地址	[Yu, Zhen]Department of Gastrointestinal Surgery,First Affiliated Hospital,Wenzhou Medical University,2 Fuxue Lane,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：243[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17702
专题	附属第一医院
通讯作者	Yu, Zhen
作者单位	1.Department of Gastrointestinal Surgery,First Affiliated Hospital,Wenzhou Medical University,2 Fuxue Lane,Wenzhou, Zhejiang,325000,China; 2.Department of Gastrointestinal Surgery,Shanghai Tenth People's Hospital Affiliated to Tongji University,Shanghai,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhuang, Cheng-Le,Huang, Dong-Dong,Pang, Wen-Yang,et al. Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer Analysis from a Large-Scale Cohort[J]. MEDICINE,2016,95(13):e3164..
APA	Zhuang, Cheng-Le., Huang, Dong-Dong., Pang, Wen-Yang., Zhou, Chong-Jun., Wang, Su-Lin., ... & Shen, Xian. (2016). Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer Analysis from a Large-Scale Cohort. MEDICINE, 95(13), e3164..
MLA	Zhuang, Cheng-Le,et al."Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer Analysis from a Large-Scale Cohort".MEDICINE 95.13(2016):e3164..