Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-kappa B

doi:10.1155/2017/4751260

科研成果详情

题名	Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-kappa B
作者	Chen, Jian 1,2; Zhang, Linlin 3; Shu, Yilai 1; Chen, Liping 2; Zhu, Min 2; Yao, Song 2; Wang, Jiabing 2; Wu, Jianzhang2; Liang, Guang2; Wu, Haitao 1; Li, Wulan2,4
发表日期	2017-12-31
发表期刊	BIOMED RESEARCH INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MONO-CARBONYL ANALOGS ; BIOLOGICAL EVALUATION ; DOWN-REGULATION ; HUMAN HEAD ; CARCINOMA ; EXPRESSION ; CANCER ; APOPTOSIS ; PATHWAY ; INHIBITION
摘要	Laryngeal carcinoma remains one of the most common malignancies, and curcumin has been proven to be effective against head and neck cancers in vitro. However, it has not yet been applied in clinical settings due to its low stability. In the current study, we synthesized 34 monocarbonyl analogues of curcumin with stable structures. CA15, which exhibited a stronger inhibited effect on laryngeal cancer cells HEp-2 but a lower toxicity on hepatic cells HL-7702 in MTT assay, was selected for further analysis. The effects of CA15 on cell viability, proliferation, migration, apoptosis, and NF-kappa B activation were measured using MTT, Transwell migration, flow cytometry, Western blot, and immunofluorescence assays in HEp-2 cells. An NF-kappa B inhibitor, BMS-345541, as well as curcumin was also tested. Results showed that CA15 induced decreased toxicity towards HL-7702 cells compared to curcumin and BMS-345541. However, similar to BMS-345541 and curcumin, CA15 not only significantly inhibited proliferation and migration and induced caspase-3-dependent apoptosis but also attenuated TNF-alpha-induced NF-kappa B activation in HEp-2 cells. These results demonstrated that curcumin analogue CA15 exhibited anticancer effects on laryngeal cancer cells via targeting of NF-kappa B.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272462, 81402839]; Zhejiang Province Natural Science Funding of China [LY17H160059]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6133
EISSN	2314-6141
卷号	2017 页码:4751260
DOI	10.1155/2017/4751260
页数	10
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS记录号	WOS:000399105600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28409156
PMC记录号	PMC5376929
SCOPUSEID	2-s2.0-85017156891
通讯作者地址	[Wu, Haitao]Departments of Otolaryngology-Head and Neck Surgery,Eye,Ear,Nose and Throat Hospital,Fudan University,Shanghai,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Immunology and Microbiology (all)
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17696
专题	药学院（分析测试中心）附属第一医院药学院（分析测试中心）_生物有机与药物化学研究中心第一临床医学院（信息与工程学院）、附属第一医院_计算机与信息管理系
通讯作者	Wu, Haitao
作者单位	1.Departments of Otolaryngology-Head and Neck Surgery,Eye,Ear,Nose and Throat Hospital,Fudan University,Shanghai,China; 2.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.Departments of Stomatology,First Affiliated Hospital,Wenzhou Medical University,Wenzhou, Zhejiang,China; 4.College of Information Science and Computer Engineering,School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China
第一作者单位	生物有机与药物化学研究中心
推荐引用方式 GB/T 7714	Chen, Jian,Zhang, Linlin,Shu, Yilai,et al. Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-kappa B[J]. BIOMED RESEARCH INTERNATIONAL,2017,2017:4751260.
APA	Chen, Jian., Zhang, Linlin., Shu, Yilai., Chen, Liping., Zhu, Min., ... & Li, Wulan. (2017). Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-kappa B. BIOMED RESEARCH INTERNATIONAL, 2017, 4751260.
MLA	Chen, Jian,et al."Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-kappa B".BIOMED RESEARCH INTERNATIONAL 2017(2017):4751260.