A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles

doi:10.1159/000493451

科研成果详情

题名	A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles
作者	Xu, Hai-Ting1,2; Guo, Jian-Chun 4; Liu, Hua-Zhen 5; Jin, Wan-Wan2,3
发表日期	2018-12-31
发表期刊	CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Geo Burned Soft clustering DAVID R
其他关键词	IMMUNE-RESPONSES ; INFECTION ; SYSTEM ; SERUM
摘要	Background/Aims: Major burn injury is one of the main severe forms of wound which lead to a mass of clinical debilitation, this study was to identify core biomarkers for the recovery of severe burned injury. Methods: Gene expression profiles (GSE19743) from the Gene Expression Omnibus (GEO) was downloaded, followed by background correction, normalization of raw microarray dataset and identification of differential expression genes (DEGs). Soft clustering of DEGs was used for the screening of gene clusters that with sustained increasing (SIG) and decreasing expression (SDG) profiles along with the recovery process of burned injury. The significantly enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of SIGs and SDGs were obtained through the Database for Annotation, Visualization, and Integrated Discovery (DAVID), based on which the miRNA-gene regulation network for SIGs and SDGs were constructed from the miRWalk database. Results: Ten clusters were obtained through soft clustering. The SIGs and SDGs were found to be closely associated with the biological processes of immune system. The miRNA-gene regulation network analysis suggested different roles between SIGs and SDGs in the recovery of severe burned injury. Furthermore, a bunch of important biomarkers were identified, which would be helpful in the treatment of burned patients. Conclusion: Our current findings suggest an interesting molecular link between transcriptional regulation potentially involved in immunosuppressive state after major burn injury, which warrants further exploration for their utilization in the treatment of major burn injury. (C) 2018 The Author(s) Published by S. Karger AG, Basel
出版者	KARGER
出版地	BASEL
ISSN	1015-8987
EISSN	1421-9778
卷号	49 期号:4 页码:1492-1498
DOI	10.1159/000493451
页数	7
WOS类目	Cell Biology ; Physiology
WOS研究方向	Cell Biology ; Physiology
WOS记录号	WOS:000447181000018
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30205399
SCOPUSEID	2-s2.0-85053764720
通讯作者地址	[Jin, Wan-Wan]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China. ; [Jin, Wan-Wan]Wenzhou Med Univ, Affiliated Hosp 2, Dept Dermatol, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Medicine (all)
TOP期刊	TOP期刊
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17683
专题	第二临床医学院、附属第二医院、育英儿童医院检验医学院（生命科学学院、生物学实验教学中心）附属第二医院附属第二医院_皮肤科
通讯作者	Jin, Wan-Wan
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Plast Surg, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Dermatol, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou, Peoples R China; 5.Second Mil Med Univ, Changhai Hosp, Dept Burn Surg, Shanghai, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 皮肤科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Xu, Hai-Ting,Guo, Jian-Chun,Liu, Hua-Zhen,et al. A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2018,49(4):1492-1498.
APA	Xu, Hai-Ting, Guo, Jian-Chun, Liu, Hua-Zhen, & Jin, Wan-Wan. (2018). A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 49(4), 1492-1498.
MLA	Xu, Hai-Ting,et al."A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 49.4(2018):1492-1498.