Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions

doi:10.3892/ol.2018.8494

科研成果详情

题名	Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions
作者	Zhao, Liang 1,2; Zhang, Zhechao 1,3; Lou, Hongyan 1,3; Liang, Jingjing 1,3; Yan, Xiaojian1,3; Li, Wenfeng1,4; Xu, Yunsheng1,5; Ou, Rongying1,3
发表日期	2018-06
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cervical cancer differentially expressed genes microRNA survival analysis
其他关键词	GENE-EXPRESSION ; PAPILLOMAVIRUS ; ANNOTATION ; ACTIVATION ; DISCOVERY ; PATHWAYS ; PROMOTER ; KINASE ; CHK1
摘要	The molecular mechanisms of cervical cancer have been minimally explored with multi-omics data. In the present study, mRNA expression profiles were analyzed and combined with predicted miRNA interactions to contribute to the characterization of the underlying regulatory mechanisms of cervical cancer. A total of 92 significantly differentially expressed genes (DEGs) were identified in 33 tumor samples by comparison with 29 normal samples. mRNA-miRNA interaction network analysis revealed that 16 out of the 92 DEGs, including checkpoint kinase 1 (CHEK1), SRY-box 17 (SOX17), centrosomal protein 55, cyclin dependent kinase inhibitor 2A (CDKN2A), and inhibitor of DNA binding 4, were the targets of 4 miRNAs which were previously reported to be involved in the regulation of cervical cancer. Tumor and normal samples could be distinctly classified into two groups based on the expression of the 16 DEGs. Furthermore, survival analysis using the SurvExpress database indicated that the 16 DEGs could individually significantly differentiate low- and high-risk cervical cancer groups. Overall, multiple biological processes are likely to participate in the progression of cervical cancer based on the pathway and function enrichment identified for the DEGs. The dysregulation of SOX17 is associated with the regulation of embryonic development, the determination of cell fate and likely promotes cancer cell transformation. The dysregulation of CHEK1 and CDKN2A further promote cancer cell proliferation by affecting the cell cycle checkpoint in response to DNA damage. The identification of critical genes and biological processes associated with cervical cancer may be beneficial for the exploration of the molecular mechanisms.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373075, 8167140, 81371748, 81571395]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1082
卷号	15 期号:6 页码:8965-8972
DOI	10.3892/ol.2018.8494
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000435149700100
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29805632
PMC记录号	PMC5958731
SCOPUSEID	2-s2.0-85046496705
通讯作者地址	[Xu, Yunsheng]Laboratory for Advanced Interdisciplinary Research,Institute of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1753
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
通讯作者	Xu, Yunsheng
作者单位	1.Laboratory for Advanced Interdisciplinary Research,Institute of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Division of PET/CT,Department of Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Departments of Gynaecology and Obstetrics,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Departments of Radiation Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Departments of Dermatovenereology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhao, Liang,Zhang, Zhechao,Lou, Hongyan,et al. Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions[J]. ONCOLOGY LETTERS,2018,15(6):8965-8972.
APA	Zhao, Liang., Zhang, Zhechao., Lou, Hongyan., Liang, Jingjing., Yan, Xiaojian., ... & Ou, Rongying. (2018). Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions. ONCOLOGY LETTERS, 15(6), 8965-8972.
MLA	Zhao, Liang,et al."Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions".ONCOLOGY LETTERS 15.6(2018):8965-8972.