A prospective observational study on utility of serum mesencephalic astrocyte-derived neurotrophic factor as a promising prognostic biomarker of severe traumatic brain injury in humans

doi:10.1016/j.cca.2023.117370

科研成果详情

题名	A prospective observational study on utility of serum mesencephalic astrocyte-derived neurotrophic factor as a promising prognostic biomarker of severe traumatic brain injury in humans
作者	Wang, Ke-Wei 1; Zhan, Cheng-Peng 2; Liu, Yong-Qi 1; Fu, Zhi-Zhan2; Qiu, Tian-Wen2; Yu, Guo-Feng 2
发表日期	2023-05-01
发表期刊	Clinica chimica acta international journal of clinical chemistry 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Biomarkers Mesencephalic astrocyte-derived neurotrophic factor Prognosis Severity Traumatic brain injury
其他关键词	ENDOPLASMIC-RETICULUM STRESS
摘要	Mesencephalic astrocyte-derived neurotrophic factor (MANF) is released under endoplasmic reticulum stress, thereby exerting neuroprotective effects. We determined whether serum MANF may be a prognostic biomarker of human severe traumatic brain injury (sTBI)., Serum MANF concentrations of 137 sTBI patients and 137 controls were quantified in this prospective cohort study. Patients with extended Glasgow outcome scale (GOSE) scores of 1-4 at post-traumatic 6 months were considered to have poor prognosis. Relationships between serum MANF concentrations and severity plus prognosis were investigated using multivariate analyses. Area under receiver operating characteristic curve (AUC) was calculated for reflecting prognostic efficiency., As compared to controls, there was a significant increase of serum MANF concentrations after sTBI (median, 18.5 ng/ml versus 3.0 ng/ml; P<0.001), which was independently correlated with Glasgow coma scale (GCS) scores [β, -3.000; 95% confidence interval (CI), -4.525--1.476; VIF, 2.216; P=0.001], Rotterdam computed tomography (CT) scores (β, 4.020; 95% CI, 1.446-6.593; VIF, 2.234; P=0.002) and GOSE scores (β, -0.056; 95% CI, -0.089--0.023; VIF, 1.743; P=0.011). Serum MANF concentrations substantially distinguished risk of poor prognosis with AUC of 0.795 (95% CI, 0.718-0.859) and its concentrations >23.9 ng/ml was predictive of poor prognosis with 67.7% sensitivity and 81.9% specificity. Serum MANF concentrations combined with GCS scores and Rotterdam CT scores displayed markedly higher prognostic predictive ability than each of them (all P<0.05). Using restricted cubic spline, there was a linear correlation between serum MANF concentrations and poor prognosis (P=0.256). Serum MANF concentrations > 23.9 ng/ml was independently associated with poor prognosis (odds ratio, 2.911; 95% CI, 1.057-8.020; P=0.039). A nomogram was built, where serum MANF concentrations > 23.9 ng/ml, GCS scores and Rotterdam CT scores were integrated. Hosmer and Lemeshow test, calibration curve and decision curve analysis demonstrated such a prediction model was comparatively stable and was of relatively high clinical benefit., Substantially increased serum MANF concentrations after sTBI are highly correlated with traumatic severity and are independently predictive of long-term poor prognosis, suggesting that serum MANF may represent a useful prognostic biochemical marker of human sTBI.
出版者	ELSEVIER
ISSN	0009-8981
EISSN	1873-3492
卷号	545
DOI	10.1016/j.cca.2023.117370
页数	8
WOS类目	Medical Laboratory Technology
WOS研究方向	Medical Laboratory Technology
WOS记录号	WOS:001054424200001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-05
URL	查看原文
PubMed ID	37137461
SCOPUSEID	2-s2.0-85154590966
通讯作者地址	[Yu, Guo-Feng]Department of Neurosurgery,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,China
Scopus学科分类	Biochemistry;Clinical Biochemistry;Biochemistry (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/175226
专题	其他_温州医科大学附属衢州医院
通讯作者	Yu, Guo-Feng
作者单位	1.The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,China; 2.Department of Neurosurgery,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,China
通讯作者单位	其他_温州医科大学附属衢州医院
推荐引用方式 GB/T 7714	Wang, Ke-Wei,Zhan, Cheng-Peng,Liu, Yong-Qi,et al. A prospective observational study on utility of serum mesencephalic astrocyte-derived neurotrophic factor as a promising prognostic biomarker of severe traumatic brain injury in humans[J]. Clinica chimica acta international journal of clinical chemistry,2023,545.
APA	Wang, Ke-Wei, Zhan, Cheng-Peng, Liu, Yong-Qi, Fu, Zhi-Zhan, Qiu, Tian-Wen, & Yu, Guo-Feng. (2023). A prospective observational study on utility of serum mesencephalic astrocyte-derived neurotrophic factor as a promising prognostic biomarker of severe traumatic brain injury in humans. Clinica chimica acta international journal of clinical chemistry, 545.
MLA	Wang, Ke-Wei,et al."A prospective observational study on utility of serum mesencephalic astrocyte-derived neurotrophic factor as a promising prognostic biomarker of severe traumatic brain injury in humans".Clinica chimica acta international journal of clinical chemistry 545(2023).