Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment

doi:10.1007/s12035-023-03342-7

科研成果详情

题名	Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment
作者	Lin, Qingxia1; Li, Kezheng 2,3; Chen, Yinuo 2,3; Xie, Jiali 4; Wu, Chunxue 5; Cui, Can 6; Deng, Binbin2
发表日期	2023-08
发表期刊	Molecular neurobiology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Advanced glycosylation end products (AGEs) Diabetic peripheral neuropathy (DPN) Interaction Oxidative stress ROS
其他关键词	ALPHA-LIPOIC ACID ; GLYCATION END-PRODUCTS ; ACETYL-L-CARNITINE ; PROTEIN-KINASE-C ; NF-KAPPA-B ; DOUBLE-BLIND ; RAT MODEL ; INFLAMMATORY RESPONSE ; INSULIN-RESISTANCE ; ANTIOXIDANT
摘要	Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has attracted much attention. The distortion in the redox balance due to the overproduction of reactive oxygen species (ROS) and the deregulation of antioxidant defense systems promotes oxidative damage in DPN. Therefore, we have focused on the role of oxidative stress in the pathogenesis of DPN and elucidated its interaction with other physiological pathways, such as the glycolytic pathway, polyol pathway, advanced glycosylation end products, protein kinase C pathway, inflammation, and non-coding RNAs. These interactions provide novel therapeutic options targeting oxidative stress for DPN. Furthermore, our review addresses the latest therapeutic strategies targeting oxidative stress for the rehabilitation of DPN. Antioxidant supplements and exercise have been proposed as fundamental therapeutic strategies for diabetic patients through ROS-mediated mechanisms. In addition, several novel drug delivery systems can improve the bioavailability of antioxidants and the efficacy of DPN.
资助项目	National Natural Science Foundation of China[81901273];Natural Science Foundation of Zhejiang Province[Q21H090076]
出版者	SPRINGER
ISSN	0893-7648
EISSN	1559-1182
卷号	60 期号:8 页码:4574-4594
DOI	10.1007/s12035-023-03342-7
页数	21
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000980197100002
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-04
URL	查看原文
PubMed ID	37115404
SCOPUSEID	2-s2.0-85153791942
通讯作者地址	[Deng, Binbin]Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neuroscience (miscellaneous);Neurology;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/175175
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Deng, Binbin
作者单位	1.Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.First School of Clinical Medicine,Wenzhou Medical University,Wenzhou,China; 4.Department of Neurology,Shanghai East Hospital,Tongji University,Shanghai,China; 5.Department of Neurology,Wencheng County People’s Hospital,Wenzhou,China; 6.Institute of Environmental Medicine,Karolinska Institutet,Stockholm,Sweden
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Qingxia,Li, Kezheng,Chen, Yinuo,et al. Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment[J]. Molecular neurobiology,2023,60(8):4574-4594.
APA	Lin, Qingxia., Li, Kezheng., Chen, Yinuo., Xie, Jiali., Wu, Chunxue., ... & Deng, Binbin. (2023). Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment. Molecular neurobiology, 60(8), 4574-4594.
MLA	Lin, Qingxia,et al."Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment".Molecular neurobiology 60.8(2023):4574-4594.