Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets

doi:10.1016/j.ejpb.2023.04.015

科研成果详情

题名	Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets
作者	Wang, Zeqing1; Jiang, Zhikai 2; Lu, Ruijie 2; Kou, Longfa3; Zhao, Ying-Zheng1,4; Yao, Qing1,4
发表日期	2023-06
发表期刊	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Islet transplantation hypoxia oxygen-carrying biomaterials oxygen-generating biomaterials photosynthetic biomaterials
其他关键词	OXIDATIVE STRESS ; PANCREATIC-ISLETS ; DRUG-DELIVERY ; ULTRASOUND ; PERFLUOROCARBON ; HEMOGLOBIN ; PHOTOSYNTHESIS ; NANOPARTICLES ; POLYLYSINE ; BILIRUBIN
摘要	Islet transplantation refers to the transfusion of healthy islet cells into the diabetic recipients and reconstruction of their endogenous insulin secretion to achieve insulin independence. It is a minimally invasive surgery that holds renewed prospect as a therapeutic method for type 1 diabetes mellitus. However, poor oxygenation in the early post-transplantation period is considered as one of the major causes of islet loss and dysfunction. Due to the metabolism chacteristics, islets required a high supply of oxygen for cell survival while a hypoxia environment would lead to severe islet loss and graft failure. Emerging strategies have been proposed, including providing external oxygen and speeding up revascularization. From the perspective of formulation science, it is feasible and practical to protect transplanted islets by oxygen-release before revascularization as opposed to local hypoxia. In this study, we review the potential formulation strategies that could provide oxygen-release by either delivering external oxygen or triggering localized oxygen generation for transplanted islets.
资助项目	Zhejiang Medical and Health Science and Technology Program[2022KY881,2023KY884];
出版者	ELSEVIER
ISSN	0939-6411
EISSN	1873-3441
卷号	187 页码:130-140
DOI	10.1016/j.ejpb.2023.04.015
页数	11
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000990238700001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-05
URL	查看原文
PubMed ID	37105362
SCOPUSEID	2-s2.0-85154067864
通讯作者地址	[Yao, Qing]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biotechnology;Pharmaceutical Science
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/175166
专题	药学院（分析测试中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院其他_温州医科大学慈溪生物医药研究院
通讯作者	Yao, Qing
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.The Second School of Medicine,Wenzhou Medical University,Wenzhou,China; 3.The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 4.Cixi Biomedical Research Institute,Wenzhou Medical University,Zhejiang,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wang, Zeqing,Jiang, Zhikai,Lu, Ruijie,et al. Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets[J]. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,2023,187:130-140.
APA	Wang, Zeqing, Jiang, Zhikai, Lu, Ruijie, Kou, Longfa, Zhao, Ying-Zheng, & Yao, Qing. (2023). Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 187, 130-140.
MLA	Wang, Zeqing,et al."Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets".European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 187(2023):130-140.