25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality

doi:10.1186/s12263-023-00727-0

科研成果详情

题名	25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality
作者	Yu, GuoSheng1; Xu, MinZhi 1; Chen, Yao 1; Ke, HaiYan 2
发表日期	2023-12
发表期刊	Genes & nutrition 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	25(OH)D Autism spectrum disorder (ASD) Genome-wide association study Mendelian randomization analysis
其他关键词	VITAMIN-D DEFICIENCY ; MENDELIAN RANDOMIZATION ; INSTRUMENTS ; SUPPLEMENTATION ; CHILDREN
摘要	To identify whether there exists a genetic correlation and causal relationship between 25(OH)D and autism spectrum disorder (ASD)., Based on large-scale genome-wide association studies, a series of genetic approaches were adopted to obtain summary statistics. Using linkage disequilibrium score regression, we assessed the shared polygenic structure between traits and performed pleiotropic analysis under composite null hypothesis (PLACO) to identify pleiotropic loci between complex traits. A bidirectional Mendelian randomization (MR) analysis was applied to investigate whether there is a causal relationship between 25(OH)D and ASD., {AbstractText=The linkage disequilibrium score regression (LDSC) showed a negative genetic correlation between 25(OH)D and ASD (rg = - 0.227, P < 0.05), and PLACO analysis identified 20 independent pleiotropic loci matched to 24 pleiotropic genes, of which the function reveals an underlying mechanism on 25(OH)D and ASD. In Mendelian randomization analysis, the inverse variance-weighted (IVW) method with OR = 0.941 (0.796, 1.112) and p < 0.474 did not show a causal relationship between 25(OH)D and ASD, while, in the reverse Mendelian randomization analysis, IVW method showed OR = 1.042 (0.930, 1.169), indicating no causal relationship either.}, This study provides evidence for a shared genetic overlap between 25(OH)D and ASD. Bidirectional MR analysis also did not show a definite causal relationship between 25(OH)D and ASD.
出版者	BMC
ISSN	1555-8932
EISSN	1865-3499
卷号	18 期号:1
DOI	10.1186/s12263-023-00727-0
页数	8
WOS类目	Genetics & Heredity ; Nutrition & Dietetics
WOS研究方向	Genetics & Heredity ; Nutrition & Dietetics
WOS记录号	WOS:000975721500001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37101109
SCOPUSEID	2-s2.0-85156146174
通讯作者地址	[Ke, HaiYan]Department of Pediatrics,Tongde hospital of Zhejiang Province,234 Gucui Road, Xihu District,Hangzhou City,310006,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Genetics
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/175162
专题	第二临床医学院，附属第二医院、育英儿童医院_儿科学
通讯作者	Ke, HaiYan
作者单位	1.Department of Pediatrics,Li shui People’s Hospital,The Sixth Affiliated Hospital,Wenzhou Medical University,Li shui,Zhejiang,323000,China; 2.Department of Pediatrics,Tongde hospital of Zhejiang Province,234 Gucui Road, Xihu District,Hangzhou City,310006,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_儿科学
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_儿科学
推荐引用方式 GB/T 7714	Yu, GuoSheng,Xu, MinZhi,Chen, Yao,et al. 25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality[J]. Genes & nutrition,2023,18(1).
APA	Yu, GuoSheng, Xu, MinZhi, Chen, Yao, & Ke, HaiYan. (2023). 25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality. Genes & nutrition, 18(1).
MLA	Yu, GuoSheng,et al."25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality".Genes & nutrition 18.1(2023).