Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response

doi:10.1016/j.bbadis.2023.166710

科研成果详情

题名	Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response
作者	Yang, Na1,2; Wang, Minxiu2; Lin, Ke2; Wang, Mengyang2; Xu, Diyun1,2; Han, Xue 3; Zhao, Xia 3; Wang, Yi2; Wu, Gaojun1; Luo, Wu1,2; Liang, Guang1,2,3; Shan, Peiren1
发表日期	2023-08
发表期刊	Biochimica et biophysica acta. Molecular basis of disease 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Dectin-1 Diabetic cardiomyopathy Inflammation Macrophages Nuclear factor-κB
其他关键词	BETA-GLUCAN RECEPTOR ; INNATE IMMUNE ; ACTIVATION ; RECOGNITION ; MECHANISMS ; INDUCTION ; TOLERANCE ; MODELS ; IMPACT ; CELLS
摘要	Cardiovascular diseases are the primary cause of mortality in patients with diabetes and obesity. Hyperglycemia and hyperlipidemia in diabetes alters cardiac function, which is associated with broader cellular processes such as aberrant inflammatory signaling. Recent studies have shown that a pattern recognition receptor called Dectin-1, expressed on macrophages, mediates pro-inflammatory responses in innate immunity. In the present study, we examined the role of Dectin-1 in the pathogenesis of diabetic cardiomyopathy. We observed increased Dectin-1 expression in heart tissues of diabetic mice and localized the source to macrophages. We then investigated the cardiac function in Dectin-1-deficient mice with STZ-induced type 1 diabetes and high-fat-diet-induced type 2 diabetes. Our results show that Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Mechanistically, our studies show that Dectin-1 is important for cell activation and induction of inflammatory cytokines in high-concentration glucose and palmitate acid (HG + PA)-challenged macrophages. Deficiency of Dectin-1 generate fewer paracrine inflammatory factors capable of causing cardiomyocyte hypertrophy and fibrotic responses in cardiac fibroblasts. In conclusion, this study provides evidence that Dectin-1 mediates diabetes-induced cardiomyopathy through regulating inflammation. Dectin-1 may be a potential target to combat diabetic cardiomyopathy.
资助项目	National Natural Science Founda-tion of China [82270282, 82271347, LY22H070004]; Natural Science Foundation of Zhejiang Province [LHDMY23H310001, 2021RC091]; Medical Health Science and Technology Project of Zhejiang Province; [82000793]
出版者	ELSEVIER
ISSN	0925-4439
EISSN	1879-260X
卷号	1869 期号:6
DOI	10.1016/j.bbadis.2023.166710
页数	13
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:001054423900001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-04
URL	查看原文
PubMed ID	37054997
SCOPUSEID	2-s2.0-85152391196
通讯作者地址	[Liang, Guang]Department of Cardiology and The Key Laboratory of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Shan, Peiren]Department of Cardiology and The Key Laboratory of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Molecular Medicine;Molecular Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/175099
专题	附属第一医院药学院（分析测试中心）
通讯作者	Liang, Guang; Shan, Peiren
作者单位	1.Department of Cardiology and The Key Laboratory of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.School of Pharmaceutical Sciences,Hangzhou Medical College,Hangzhou,Zhejiang,China
第一作者单位	附属第一医院; 药学院（分析测试中心）; 生物有机与药物化学研究中心
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Na,Wang, Minxiu,Lin, Ke,et al. Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response[J]. Biochimica et biophysica acta. Molecular basis of disease,2023,1869(6).
APA	Yang, Na., Wang, Minxiu., Lin, Ke., Wang, Mengyang., Xu, Diyun., ... & Shan, Peiren. (2023). Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response. Biochimica et biophysica acta. Molecular basis of disease, 1869(6).
MLA	Yang, Na,et al."Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response".Biochimica et biophysica acta. Molecular basis of disease 1869.6(2023).