科研成果详情

题名Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-KB Signaling
作者
发表日期2023
发表期刊DRUG DESIGN DEVELOPMENT AND THERAPY   影响因子和分区
语种英语
原始文献类型Article
关键词berberine sepsis inflammation cell differentiation immunodeficiency T lymphocyte
其他关键词SEPSIS ; CELLS ; INFLAMMATION ; DYSFUNCTION ; INHIBITION ; EXPRESSION ; MORTALITY ; IMBALANCE ; PATHWAY
摘要Purpose: A common complication of sepsis is acute lung injury (ALI), which is associated with an acute onset, rapid disease changes, and high mortality. Regulatory T (Treg) and T helper 17 (Th17) cells comprise CD4+ T cell subsets, which strongly influence inflammation during ALI. In this study, we investigated the effect of berberine (BBR), an antioxidant, anti-inflammatory, and immunomodulatory drug, on the inflammatory response and immune state in mice with sepsis.Methods: A mouse model of cecal ligation and puncture (CLP) was established. The mice were intragastrically administered 50 mg/ kg BBR. We used histological techniques to evaluate inflammatory tissue injury and flow cytometry for analyzing Treg/Th17 levels. We also assessed NF-KB signaling pathways by Western blotting assays and immunofluorescence staining. Enzyme-linked immuno-sorbent assay (ELISA) was performed to measure the content of cytokines. Results: Treatment with BBR considerably mitigated lung injury while improving survival, post-cecal ligation, and puncture (CLP). Treatment with BBR ameliorated pulmonary edema and hypoxemia in septic mice and inhibited the NF-KB signaling pathway. BBR also increased Treg cells and decreased Th17 proportions in the spleen and lung tissue of CLP-treated mice. Blocking Treg cells weakened the protective effect of BBR on sepsis-associated lung injury. Conclusion: Overall, these results suggested that BBR is a potential therapeutic agent for sepsis.
资助项目Wenzhou Municipal Science and Technology Project [Y2020094]; Natural Science Foundation of Zhejiang Province [LQ22H150003]; National Key R&D Program of China [2018YFC2000305]
出版者DOVE MEDICAL PRESS LTD
ISSN1177-8881
卷号17页码:1139-1151
DOI10.2147/DDDT.S401293
页数13
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
WOS记录号WOS:000970762600001
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID37077411
SCOPUSEID2-s2.0-85152978290
通讯作者地址[Ye, Yumei]Department of Ultrasound Imaging,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类Pharmacology;Pharmaceutical Science;Drug Discovery
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/174844
专题附属第一医院
附属第一医院_超声影像科
通讯作者Ye, Yumei
作者单位
1.Department of Emergency,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China;
2.Department of Critical Care Medicine,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Zhejiang,Jinhua,China;
3.Department of Intensive Care Unit,Wenzhou Longwan District First People’s Hospital,Zhejiang,Wenzhou,China;
4.Department of Ultrasound Imaging,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
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GB/T 7714
Chen, Longwang,Liu, Xinyong,Wang, Xuetao,et al. Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-KB Signaling[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2023,17:1139-1151.
APA Chen, Longwang, Liu, Xinyong, Wang, Xuetao, Lu, Zhongqiu, & Ye, Yumei. (2023). Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-KB Signaling. DRUG DESIGN DEVELOPMENT AND THERAPY, 17, 1139-1151.
MLA Chen, Longwang,et al."Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-KB Signaling".DRUG DESIGN DEVELOPMENT AND THERAPY 17(2023):1139-1151.

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