Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

doi:10.3389/fphar.2023.1067402

科研成果详情

题名	Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway
作者	Lou, Lejing1; Wang, Min 1; He, Jingjing 1; Yang, Song1; Meng, Fanxi 2; Wang, Shijia1; Jin, Xiao1; Cai, Jihao 3; Cai, Chang1
发表日期	2023-03-09
发表期刊	Frontiers in pharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Article
关键词	LPS Nrf2 acute lung injury ferroptosis urolithin a
其他关键词	RESPIRATORY-DISTRESS-SYNDROME ; PREVENTION ; APOPTOSIS
摘要	Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates. Urolithin A (UA) is a pomegranate intestinal flora metabolite with anti-inflammatory, antioxidant, and anti-aging properties. Ferroptosis is a critical factor in lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, the link between UA and ferroptosis is unknown. The purpose of this research was to look into the role of UA in regulating LPS-induced ferroptosis in ALI. The current study used LPS to injure two models, one BEAS-2B cell injury model and one ALI mouse model. UA effectively alleviated LPS-induced ALI compared to the LPS group by lowering in vivo lung wet/dry weight ratio, reactive oxygen species, and malondialdehyde production, as well as superoxide dismutase, catalase, and glutathione depletion. Furthermore, by increasing GPX4 and SLC7A11 expression and decreasing Fe2+ levels, lung histopathological damage, inflammatory cytokine secretion, and ferroptosis levels can be significantly reduced. The Keap1-Nrf2/HO-1 pathway was upregulated by UA, which inhibited LPS-induced ALI and ferroptosis. ML385 inhibited UA's protective effect against LPS-induced ALI. These findings suggested that UA could be a novel potential therapeutic target for ALI
资助项目	General Program (Key Program, Major Research Plan) of the National Natural Science Foundation of China [81470225]; Basic Science Foundation of Wenzhou City [Y2020003]
出版者	FRONTIERS MEDIA SA
ISSN	1663-9812
EISSN	1663-9812
卷号	14
DOI	10.3389/fphar.2023.1067402
页数	14
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000957600800001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36969874
SCOPUSEID	2-s2.0-85150623704
通讯作者地址	[Cai, Chang]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174160
专题	第一临床医学院（信息与工程学院）、附属第一医院药学院（分析测试中心）附属第一医院仁济学院
通讯作者	Cai, Chang
作者单位	1.Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,China; 3.Renji College of Wenzhou Medical University,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
推荐引用方式 GB/T 7714	Lou, Lejing,Wang, Min,He, Jingjing,et al. Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway[J]. Frontiers in pharmacology,2023,14.
APA	Lou, Lejing., Wang, Min., He, Jingjing., Yang, Song., Meng, Fanxi., ... & Cai, Chang. (2023). Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway. Frontiers in pharmacology, 14.
MLA	Lou, Lejing,et al."Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway".Frontiers in pharmacology 14(2023).