Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing

doi:10.3389/fbioe.2021.740863

科研成果详情

题名	Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing
作者	Li, Yuan 1,2; Jiang, Shishuang2; Song, Liwan 2; Yao, Zhe1; Zhang, Junwen 3; Wang, Kangning 2; Jiang, Liping2; He, Huacheng 3; Lin, Cai1; Wu, Jiang1,2
发表日期	2021-10-08
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	pressure ulcer zwitterionic non-fouling hydrogel autophagy
其他关键词	GROWTH-FACTORS ; CANCER-CELLS ; WOUNDS ; PROLIFERATION ; PI3K/AKT/MTOR ; REGENERATION ; PATHOGENESIS ; EXPRESSION ; APOPTOSIS ; COLLAGEN
摘要	Pressure ulcer (PU) is a worldwide problem that is hard to heal because of its prolonged inflammatory response and impaired ECM deposition caused by local hypoxia and repeated ischemia/reperfusion. Our previous study discovered that the non-fouling zwitterionic sulfated poly (sulfobetaine methacrylate) (SBMA) hydrogel can improve PU healing with rapid ECM rebuilding. However, the mechanism of the SBMA hydrogel in promoting ECM rebuilding is unclear. Therefore, in this work, the impact of the SBMA hydrogel on ECM reconstruction is comprehensively studied, and the underlying mechanism is intensively investigated in a rat PU model. The in vivo data demonstrate that compared to the PEG hydrogel, the SBMA hydrogel enhances the ECM remolding by the upregulation of fibronectin and laminin expression as well as the inhibition of MMP-2. Further investigation reveals that the decreased MMP-2 expression of zwitterionic SBMA hydrogel treatment is due to the activation of autophagy through the inhibited PI3K/Akt/mTOR signaling pathway and reduced inflammation. The association of autophagy with ECM remodeling may provide a way in guiding the design of biomaterial-based wound dressing for chronic wound repair.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LGF19H180008]; Zhejiang Qianjiang Talent project [QJD1803015]; Wenzhou Science and Technology Bureau [Y2020136]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-4185
EISSN	2296-4185
卷号	9 页码:740863
DOI	10.3389/fbioe.2021.740863
页数	63
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:000710950100001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20214311079237
EI主题词	Cell death
URL	查看原文
PubMed ID	34692658
PMC记录号	PMC8531594
SCOPUSEID	2-s2.0-85117722459
通讯作者地址	[Lin, Cai]School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,China ; [Wu, Jiang]School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,China ; [He, Huacheng]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,China
Scopus学科分类	Biotechnology;Bioengineering;Histology;Biomedical Engineering
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17401
专题	药学院（分析测试中心）附属第一医院_烧伤科
通讯作者	He, Huacheng; Lin, Cai; Wu, Jiang
作者单位	1.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,China; 2.Department of Burn,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,China
第一作者单位	药学院（分析测试中心）; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Li, Yuan,Jiang, Shishuang,Song, Liwan,et al. Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2021,9:740863.
APA	Li, Yuan., Jiang, Shishuang., Song, Liwan., Yao, Zhe., Zhang, Junwen., ... & Wu, Jiang. (2021). Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 9, 740863.
MLA	Li, Yuan,et al."Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 9(2021):740863.