The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages

doi:10.1016/j.bjid.2015.07.003

科研成果详情

题名	The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages
作者	Liu, Huanle1; Lv, Jingnan 1; Qi, Xiuqin 1; Ding, Yu 1; Li, Dan1; Hu, Longhua 3; Wang, Liangxing2; Yu, Fangyou1
发表日期	2015-09
发表期刊	BRAZILIAN JOURNAL OF INFECTIOUS DISEASES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Staphylococcus aureus sdr genes Clonal lineages
其他关键词	METHICILLIN-RESISTANT ; SURFACE-PROTEINS ; VIRULENCE GENES ; EXOTOXINS ; STRAINS
摘要	The serine-aspartate repeat proteins (Sdr) are members of a family of surface proteins and contribute to the pathogenicity of Staphylococcus aureus. Among 288 S. aureus isolates including 158 and 130 associated with skin and soft tissue infections and bloodstream infection, respectively; 275 (95.5%) were positive for at least one of three sdr genes tested. The positivity rates for sdrC, sdrD, and sdrE among S. aureus isolates were 87.8% (253/288), 63.9% (184/288), and 68.1% (196/288), respectively. 224 (77.8%) of 288 isolates were concomitantly positive for two or three sdr genes. There was an association between carriage of sdrE and methicillin-resistant S. aureus (MRSA) isolates, while the carriage rates of sdrC and sdrD in MRSA isolates were similar to those in methicillin-sensitive S. aureus (MSSA) isolates. The prevalence of co-existence of sdrC and sdrE among MRSA isolates was significantly higher than that among MSSA isolates (p < 0.05). All ST1, ST5, ST7, and ST25 isolates were positive for sdrD. While all ST121 and ST398 isolates were negative for sdrD. All ST59 and ST88 isolates were positive for sdrE. All ST1 isolates were concomitantly positive for sdrC and sdrD. Concomitant carriage of sdrC, sdrD, and sdrE was found among all ST5, 75.0% (9/12) of ST1, 69.2% (9/13) of ST6, 78.6% (11/14) of ST25, and 90.9% (20/22) of ST88 isolates. sdrD was linked to CG5, CC7 and CC88 isolates, especially CC88 isolates. There was a strong association between the presence of sdrE and CC59, CC88, and CG5 isolates. A significant correlation between concomitant carriage of sdrC, sdrD, and sdrE and CC88 isolates was found. sdrC-positive, sdrD-positive and sdrE-negative gene profile was significantly associated with CC7 clone. There was an association between sdrC-positive, sdrD-negative, and sdrE-positive gene profile and CC59 isolates. A correlation between sdrC-positive, sdrD-negative, and sdrE-negative gene profile and CC121 clone was found. More CC59 isolates carried sdrC-negative, sdrD-negative, and sdrE-positive gene profile relative to other four CCs isolates. All ST1 and ST5, 95.2% (20/21) of ST188 and 95.2% (20/21) of ST630 isolates were positive for sdrC. Taken together, our investigation indicated that different S. aureus lineages were associated with specific patterns of carriage of sdr genes. (C) 2015 Elsevier Editora Ltda. All rights reserved.
资助项目	National Natural Science Fund of ChinaNational Natural Science Foundation of China (NSFC) [81271906H2002]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	1413-8670
EISSN	1678-4391
卷号	19 期号:5 页码:498-502
DOI	10.1016/j.bjid.2015.07.003
页数	5
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
WOS记录号	WOS:000362104000008
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26277345
SCOPUSEID	2-s2.0-84942551082
通讯作者地址	[Yu, Fangyou]Department of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Microbiology (medical);Infectious Diseases
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17342
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_呼吸内科
通讯作者	Yu, Fangyou
作者单位	1.Department of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Respiratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Laboratory Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Liu, Huanle,Lv, Jingnan,Qi, Xiuqin,et al. The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages[J]. BRAZILIAN JOURNAL OF INFECTIOUS DISEASES,2015,19(5):498-502.
APA	Liu, Huanle., Lv, Jingnan., Qi, Xiuqin., Ding, Yu., Li, Dan., ... & Yu, Fangyou. (2015). The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages. BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 19(5), 498-502.
MLA	Liu, Huanle,et al."The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages".BRAZILIAN JOURNAL OF INFECTIOUS DISEASES 19.5(2015):498-502.