Reviewing the mechanism of propofol addiction

doi:10.1080/26895293.2023.2174708

科研成果详情

题名	Reviewing the mechanism of propofol addiction
作者	Zhong, Tianhao 1; Lin, Yuyan 1; Zhuge, Ruohuai 1; Lin, Yujie 1; Huang, Bingwu1,2,3; Zeng, Ruifeng 1,2,3
发表期刊	ALL LIFE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Propofol anaesthesia neurotransmitter agents substance addiction neural pathways
其他关键词	CONDITIONED PLACE PREFERENCE ; NUCLEUS-ACCUMBENS CORE ; GLUCOCORTICOID-RECEPTOR ; ABUSE ; COCAINE ; INVOLVEMENT ; ANESTHESIA ; STRESS ; D1 ; SENSITIZATION
摘要	Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment. However, accumulating clinical and experimental evidence has shown that propofol can potentially be abused and is prone to causing addiction. To further understand the underlying mechanism of propofol addiction, our review places emphasis on explaining the roles of the mesolimbic, noradrenergic, and nitrergic systems in propofol addiction. We have focused on the role of the gamma-aminobutyric acid, glucocorticoid, N-methyl-D-aspartic acid, adenosine A2A, and corticotropin-releasing factor receptors in the mesolimbic system in forming and maintaining propofol addiction. Furthermore, we have attempted to clarify the relationship between the dopaminergic pathway, extracellular signal-regulated kinase signalling pathway, and the ventral tegmental area-nucleus accumbens circuit in the mesolimbic system.Key Policy Highlights1. Although propofol is effective in inducing and maintaining anesthesia, it is prone to cause abuse and addiction.2. The mesolimbic, noradrenergic, and nitrergic systems are involved in propofol addiction.3. The dopaminergic pathway, extracellular signal-regulated kinase signalling pathway, and the ventral tegmental area-nucleus accumbens circuit in the mesolimbic system may be involved in the maintenance of propofol addiction.
资助项目	Basic Public Welfare Research Project of Zhejiang Province, People's republic of China [LGD20H090003]; Doctoral Fund of The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
出版者	TAYLOR & FRANCIS LTD
ISSN	2689-5293
EISSN	2689-5307
卷号	16 期号:1
DOI	10.1080/26895293.2023.2174708
页数	9
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000927210000001
收录类别	SCIE ; SCOPUS
发表日期	2023-12-31
URL	查看原文
Scopus记录号	2-s2.0-85147970337
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/173056
专题	第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Zeng, Ruifeng
作者单位	1.Second Clin Med Coll Wenzhou Med Univ, Wenzhou, Peoples R China; 2.Yuying Childrens Hosp Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Wenzhou, Peoples R China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhong, Tianhao,Lin, Yuyan,Zhuge, Ruohuai,et al. Reviewing the mechanism of propofol addiction[J]. ALL LIFE,2023,16(1).
APA	Zhong, Tianhao, Lin, Yuyan, Zhuge, Ruohuai, Lin, Yujie, Huang, Bingwu, & Zeng, Ruifeng. (2023). Reviewing the mechanism of propofol addiction. ALL LIFE, 16(1).
MLA	Zhong, Tianhao,et al."Reviewing the mechanism of propofol addiction".ALL LIFE 16.1(2023).