A novel nomogram to predict survival of patients with hepatocellular carcinoma after transarterial chemoembolization: a tool for retreatment decision making

doi:10.21037/atm-22-6513

科研成果详情

题名	A novel nomogram to predict survival of patients with hepatocellular carcinoma after transarterial chemoembolization: a tool for retreatment decision making
作者	Li, Jie 1; Li, Chengjun1; Zhu, Guoqing2; Yang, Junhui 1; Zhang, Yunjie1; Yu, Zhijie1; Xia, Jinglin1,2,3,4
发表日期	2023-01-13
发表期刊	ANNALS OF TRANSLATIONAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Nomogram transarterial chemoembolization (TACE) hepatocellular carcinoma (HCC)
其他关键词	TACE ; SORAFENIB ; MRECIST
摘要	Background: There is still no standardized policy regarding how to identify patients who are not benefiting from transarterial chemoembolization (TACE). We aimed to establish and validate a nomogram model to predict the survival rate of hepatocellular carcinoma (HCC) patients after TACE.Methods: A total of 578 HCC patients undergoing initial TACE at the First Affiliated Hospital of Wenzhou Medical University were retrospectively recruited to the study. The patients were randomly divided into 2 cohorts: a training cohort (n=405) and a validation cohort (n=173). To develop the nomogram, Cox regression analyses were used to identify independent risk factors. The performances of the nomogram were assessed by concordance index (C-index), calibration curves, and decision curve analysis (DCA), and were compared to 4 developed prognostic models.Results: We used 5 independent risk factors including postoperative albumin-bilirubin (ALBI) grade, tumor diameter, number of tumors, portal vein invasion, and tumor response to develop the nomogram. Calibration curves showed consistency between the nomogram and the actual observation. The C-index of the nomogram was 0.753 [95% confidence interval (CI): 0.722, 0.784], which was higher than the other prognostic models (P<0.001). The DCA showed that the nomogram had the highest net benefit among the models. According to predicted survival risk, the nomogram could divide patients into 3 groups (P<0.001). All the results were verified in the validation cohort.Conclusions: This study developed and validated a nomogram model for HCC patients undergoing TACE, which could predict the survival rate and provide support for further treatment strategies.
资助项目	National Natural Science Foundation of China [81972233]; Major Scientific and Technological Innovation Project of Wenzhou Science and Technology Bureau [ZY2021009]
出版者	AME PUBLISHING COMPANY
ISSN	2305-5839
EISSN	2305-5847
卷号	11 期号:2
DOI	10.21037/atm-22-6513
页数	13
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000917019000001
收录类别	SCIE ; PUBMED
在线发表日期	2023-01
URL	查看原文
PubMed ID	36819596
通讯作者地址	[Xia, Jinglin]Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/173052
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_介入科
通讯作者	Xia, Jinglin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Intervent Radiol, Wenzhou, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Li, Jie,Li, Chengjun,Zhu, Guoqing,et al. A novel nomogram to predict survival of patients with hepatocellular carcinoma after transarterial chemoembolization: a tool for retreatment decision making[J]. ANNALS OF TRANSLATIONAL MEDICINE,2023,11(2).
APA	Li, Jie., Li, Chengjun., Zhu, Guoqing., Yang, Junhui., Zhang, Yunjie., ... & Xia, Jinglin. (2023). A novel nomogram to predict survival of patients with hepatocellular carcinoma after transarterial chemoembolization: a tool for retreatment decision making. ANNALS OF TRANSLATIONAL MEDICINE, 11(2).
MLA	Li, Jie,et al."A novel nomogram to predict survival of patients with hepatocellular carcinoma after transarterial chemoembolization: a tool for retreatment decision making".ANNALS OF TRANSLATIONAL MEDICINE 11.2(2023).