Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy

doi:10.1016/j.cej.2022.140619

科研成果详情

题名	Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy
作者	Kuang, Gaizhen 1,2,3; Zhang, Qingfei 2; Yu, Yunru 2; Ding, Xiaoya 2; Sun, Weijian4; Shen, Xian3; Zhao, Yuanjin 1,2,3
发表日期	2023
发表期刊	CHEMICAL ENGINEERING JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Immunotherapy Cancer vaccine Tumor microenvironment Biomaterial Tumor therapy
其他关键词	SUPPRESSOR-CELLS ; DELIVERY ; ANTIGEN ; AGONIST ; SYSTEM
摘要	Immunotherapy has played an important role in the treatment of malignant tumors. Efforts in this area are focused on exploiting a facile scaffold-based cancer vaccine with admirable efficacy and favorable property for tumor immunotherapy. Herein, an implantable sponge-nanofiber Janus scaffold with lyophilization-inactivated cancer cells, immune adjuvant imiquimod, and 5-fluorouracil (5-FU) spatially loading has been developed for tumor postoperative immuno-chemotherapy. The inactivated cancer cells and imiquimod encapsulated macro-porous sponge of the scaffold can act as an immune niche to initiate a potent immune response. While the 5-FU loaded nanofibers can not only enhance the mechanical property of the scaffold, but also increase the anti-tumor immunity of the scaffold by directly killing cancer cells and depleting myeloid-derived suppressor cells to remodel the tumor immunosuppression microenvironment. Based on these features, the excellent anti-recurrence and anti-metastasis efficiency of the composited Janus scaffold have been demonstrated in the mouse breast tumor model. Thus, it is convinced that the proposed Janus scaffold spatially encapsulated with lyophilization-inactivated cancer cell vaccines and chemotherapeutic agents will provide novel sights for combination therapy after tumor surgery.
资助项目	National Key Research and Development Program of China [2020YFA0908200]; National Natural Science Foundation of China [32201118, 52073060, 52103196]; Guangdong Basic and Applied Basic Research Foundation [2021B1515120054]; Shenzhen Fundamental Research Program [JCYJ20190813152616459, JCYJ20210324133214038]
出版者	ELSEVIER SCIENCE SA
ISSN	1385-8947
EISSN	1873-3212
卷号	455
DOI	10.1016/j.cej.2022.140619
页数	10
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS研究方向	Engineering
WOS记录号	WOS:000931237000001
收录类别	SCIE ; EI ; SCOPUS
在线发表日期	2023-02
EI入藏号	20225013254460
EI主题词	Cancer cells
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.3 Biomechanics, Bionics and Biomimetics ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 761 Nanotechnology ; 933 Solid State Physics
URL	查看原文
SCOPUSEID	2-s2.0-85143854395
通讯作者地址	[Sun, Weijian]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China
Scopus学科分类	Chemistry (all);Environmental Chemistry;Chemical Engineering (all);Industrial and Manufacturing Engineering
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/173023
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Sun, Weijian
作者单位	1.Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China; 2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325001,China; 3.Department of Gastrointestinal Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325035,China; 4.Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	附属第一医院
推荐引用方式 GB/T 7714	Kuang, Gaizhen,Zhang, Qingfei,Yu, Yunru,et al. Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy[J]. CHEMICAL ENGINEERING JOURNAL,2023,455.
APA	Kuang, Gaizhen., Zhang, Qingfei., Yu, Yunru., Ding, Xiaoya., Sun, Weijian., ... & Zhao, Yuanjin. (2023). Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy. CHEMICAL ENGINEERING JOURNAL, 455.
MLA	Kuang, Gaizhen,et al."Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy".CHEMICAL ENGINEERING JOURNAL 455(2023).