Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica

doi:10.1016/j.drup.2023.100953

科研成果详情

题名	Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica
作者	Wu, Yuye 1; Jiang, Tian1,2; Bao, Danni 3; Yue, Meina 4; Jia, Huiqiong 5,6; Wu, Jianyong 7; Ruan, Zhi 1
发表日期	2023-05
发表期刊	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Carbapenem resistance Global dissemination Phylogeography Salmonella enterica
摘要	Due to the frequent international and intercontinental transmission of multidrug-resistant bacteria, it is imperative to understand the epidemiology, phylogeography, and population structure of carbapenem-resistant Salmonella enterica (CRSE) across the globe. During the period of 2015-2022, two blaNDM-carrying S. enterica strains were recovered from 3695 Salmonella strains in four hospitals in China. The global phylogenetic framework and geographical distribution of CRSE were defined by our recently updated bacterial whole genome sequence typing and source tracking database BacWGSTdb 2.0 to measure the diversity and evolutionary relatedness in context with epidemiological metadata. Phylogeny for all carbapenemase gene-harboring plasmids in S. enterica based on the pairwise Mash differences was also constructed to evaluate the potential transmission of these plasmids in a global context. A large-scale phylogenetic analysis grouped global CRSE into nine distinct clades. The small genetic distance (< 20 SNPs) between 198 pairs of CRSE suggested the presence of clonal transmission. Global CRSE have significant geographical variations, which was associated with the clonal lineages and carbapenemase genes. Carbapenemase gene-carrying plasmids with a high degree of similarity have surfaced in various hosts and countries. The widespread of multiple-replicon plasmids that offer a great capacity to accommodate multiple antimicrobial resistance genes is continuously enhancing the potential risk of CRSE isolates to propagate globally. Both clonal spread of strains and horizontal transfer of carbapenemase gene-harboring plasmids contribute to the global dissemination of CRSE. Our findings on the worldwide spread and transmission dynamics of this emerging bacterium has increased the knowledge of its global epidemics. Continued epidemiological surveillance is necessary to prevent global outbreak of multidrug-resistant Salmonella infections
资助项目	National Natural Science Foundation of China [82102436]; Zhejiang Provincial Natural ScienceFoundation of China [LR23H200001, LY21H190001, LQ22H200001]; Zhejiang Provincial Medical and Health Science and Technology Plan [2023KY414, 2022KY1013, 2020RC066, 2021RC007]
出版者	CHURCHILL LIVINGSTONE
ISSN	1368-7646
EISSN	1532-2084
卷号	68
DOI	10.1016/j.drup.2023.100953
页数	6
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000950629200001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-02
URL	查看原文
PubMed ID	36841133
SCOPUSEID	2-s2.0-85148752776
自科自定义期刊分类	T3(B)类
通讯作者地址	[Ruan, Zhi]Department of Clinical Laboratory,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,China
Scopus学科分类	Oncology;Pharmacology;Cancer Research;Infectious Diseases;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172843
专题	温州医科大学
通讯作者	Ruan, Zhi
作者单位	1.Department of Clinical Laboratory,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.Department of Clinical Laboratory,The Affiliated Wenling Hospital,Wenzhou Medical University,Taizhou,China; 3.Department of Clinical Laboratory,Sanmen People's Hospital,Taizhou,China; 4.Department of Clinical Laboratory,Hangzhou Children's Hospital,Hangzhou,China; 5.Department of Laboratory Medicine,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China; 6.Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province,Hangzhou,China; 7.Department of Clinical Laboratory,The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China
推荐引用方式 GB/T 7714	Wu, Yuye,Jiang, Tian,Bao, Danni,et al. Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica[J]. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy,2023,68.
APA	Wu, Yuye., Jiang, Tian., Bao, Danni., Yue, Meina., Jia, Huiqiong., ... & Ruan, Zhi. (2023). Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 68.
MLA	Wu, Yuye,et al."Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica".Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 68(2023).