科研成果详情

题名Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity
作者
发表日期2023-03-15
发表期刊Toxicology   影响因子和分区
语种英语
原始文献类型Journal Article
关键词Graphene quantum dots Locomotor activity Synaptic plasticity Thigmotaxis
其他关键词CARBON NANOTUBES ; TOXICITY ; NANOTOXICITY ; DEPENDENCE ; EXPOSURE ; OXIDE
摘要Graphene quantum dots (GQDs) recently gain much attention for its medicinal values in treating diseases such as neurodegeneration and inflammations. However, owing to the high permeability of GQDs across the blood-brain barrier, whether its retention in the central nervous system (CNS) perturbs neurobehaviors remains less reported. In the study, the locomotion of zebrafish larvae (Danio rerio) was fully evaluated when administrated by two GQDs in a concentration gradient, respectively as reduced-GQDs (R-GQDs): 150, 300, 600, 1200, and 2400 g/L, and graphene oxide QDs (GOQDs): 60, 120, 240, 480, and 960 g/L. After exposure, the larvae were kept for locomotion analysis within one week's depuration. Substantial data showed that the basal locomotor activity of zebrafish larvae was not significantly changed by both two GQDs at low concentrations while weakened greatly with the increase of concentrations, and the total ATP levels of zebrafish larvae were also found to decrease significantly when exposed to the highest concentrations of GQDs. Next, the thigmotactic effect was observed to be remarkably induced in larvae by both two GQDs at any concentrations during exposure, and remained strong in larvae treated by high concentrations of R-GQDs after 7 days' depuration. To be noted, we found that GQDs affected the synaptic plasticity via downregulating the mRNA levels of NMDA and AMPA receptor family members as well as the total glutamine levels in zebrafish larvae. Together, our study presented robust data underlying the locomotor abnormalities aroused by GQDs in zebrafish larvae and indicated the potential adverse effects of GQDs on synaptic plasticity.
资助项目Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province [2021ZYD0068]; Sichuan Medical Association [S20022]; Fundamental Research Funds for the Central Universities from Ministry of Education, PRC [2015CP001]; Ministry of Education, PRC
出版者ELSEVIER IRELAND LTD
ISSN0300-483X
EISSN1879-3185
卷号487
DOI10.1016/j.tox.2023.153462
页数13
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS研究方向Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000948104000001
收录类别PUBMED ; SCIE ; SCOPUS
在线发表日期2023-02
URL查看原文
PubMed ID36805088
SCOPUSEID2-s2.0-85148339301
通讯作者地址[Deng, Shun]Sichuan Provincial Orthopedic Hospital,Chengdu,610041,China
Scopus学科分类Toxicology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/172783
专题附属第二医院_科研中心
通讯作者Deng, Shun
作者单位
1.Sichuan Provincial Orthopedic Hospital,Chengdu,610041,China;
2.School of sports medicine and physical therapy,Beijing Sport University,Beijing,100084,China;
3.School of sports medicine and health,Chengdu Sport University,Chengdu,610041,China;
4.Scientific Research Center,Wenzhou Medical University,Wenzhou,325035,China;
5.Chongqing institute of green and intelligent technology,Chinese Academy of Science,Chongqing,400714,China
推荐引用方式
GB/T 7714
Deng, Shun,Zhang, Enming,Tao, Junyu,et al. Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity[J]. Toxicology,2023,487.
APA Deng, Shun., Zhang, Enming., Tao, Junyu., Zhao, Yunyang., Huo, Wenbo., ... & Bian, Wanping. (2023). Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity. Toxicology, 487.
MLA Deng, Shun,et al."Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity".Toxicology 487(2023).

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