题名 | Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity |
作者 | |
发表日期 | 2023-03-15 |
发表期刊 | Toxicology 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Journal Article |
关键词 | Graphene quantum dots Locomotor activity Synaptic plasticity Thigmotaxis |
其他关键词 | CARBON NANOTUBES ; TOXICITY ; NANOTOXICITY ; DEPENDENCE ; EXPOSURE ; OXIDE |
摘要 | Graphene quantum dots (GQDs) recently gain much attention for its medicinal values in treating diseases such as neurodegeneration and inflammations. However, owing to the high permeability of GQDs across the blood-brain barrier, whether its retention in the central nervous system (CNS) perturbs neurobehaviors remains less reported. In the study, the locomotion of zebrafish larvae (Danio rerio) was fully evaluated when administrated by two GQDs in a concentration gradient, respectively as reduced-GQDs (R-GQDs): 150, 300, 600, 1200, and 2400 g/L, and graphene oxide QDs (GOQDs): 60, 120, 240, 480, and 960 g/L. After exposure, the larvae were kept for locomotion analysis within one week's depuration. Substantial data showed that the basal locomotor activity of zebrafish larvae was not significantly changed by both two GQDs at low concentrations while weakened greatly with the increase of concentrations, and the total ATP levels of zebrafish larvae were also found to decrease significantly when exposed to the highest concentrations of GQDs. Next, the thigmotactic effect was observed to be remarkably induced in larvae by both two GQDs at any concentrations during exposure, and remained strong in larvae treated by high concentrations of R-GQDs after 7 days' depuration. To be noted, we found that GQDs affected the synaptic plasticity via downregulating the mRNA levels of NMDA and AMPA receptor family members as well as the total glutamine levels in zebrafish larvae. Together, our study presented robust data underlying the locomotor abnormalities aroused by GQDs in zebrafish larvae and indicated the potential adverse effects of GQDs on synaptic plasticity. |
资助项目 | Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province [2021ZYD0068]; Sichuan Medical Association [S20022]; Fundamental Research Funds for the Central Universities from Ministry of Education, PRC [2015CP001]; Ministry of Education, PRC |
出版者 | ELSEVIER IRELAND LTD |
ISSN | 0300-483X |
EISSN | 1879-3185 |
卷号 | 487 |
DOI | 10.1016/j.tox.2023.153462 |
页数 | 13 |
WOS类目 | Pharmacology & Pharmacy ; Toxicology |
WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
WOS记录号 | WOS:000948104000001 |
收录类别 | PUBMED ; SCIE ; SCOPUS |
在线发表日期 | 2023-02 |
URL | 查看原文 |
PubMed ID | 36805088 |
SCOPUSEID | 2-s2.0-85148339301 |
通讯作者地址 | [Deng, Shun]Sichuan Provincial Orthopedic Hospital,Chengdu,610041,China |
Scopus学科分类 | Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/172783 |
专题 | 附属第二医院_科研中心 |
通讯作者 | Deng, Shun |
作者单位 | 1.Sichuan Provincial Orthopedic Hospital,Chengdu,610041,China; 2.School of sports medicine and physical therapy,Beijing Sport University,Beijing,100084,China; 3.School of sports medicine and health,Chengdu Sport University,Chengdu,610041,China; 4.Scientific Research Center,Wenzhou Medical University,Wenzhou,325035,China; 5.Chongqing institute of green and intelligent technology,Chinese Academy of Science,Chongqing,400714,China |
推荐引用方式 GB/T 7714 | Deng, Shun,Zhang, Enming,Tao, Junyu,et al. Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity[J]. Toxicology,2023,487. |
APA | Deng, Shun., Zhang, Enming., Tao, Junyu., Zhao, Yunyang., Huo, Wenbo., ... & Bian, Wanping. (2023). Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity. Toxicology, 487. |
MLA | Deng, Shun,et al."Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity".Toxicology 487(2023). |
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