Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients

doi:10.1007/s00406-022-01525-2

科研成果详情

题名	Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients
作者	Fang, Xinyu 1; Wu, Zenan 2; Wen, Lu 3; Zhang, Yaoyao4; Wang, Dandan 2; Yu, Lingfang 2; Wang, Yewei 2; Chen, Yan 2; Chen, Lei5; Liu, Hongyang 4; Tang, Wei 4,5; Zhang, Xiangrong 1; Zhang, Chen 2,6
发表日期	2023-08
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	Schizophrenia Depressive symptoms Rumination Childhood trauma
其他关键词	SPECTRUM DISORDERS ; PSYCHOTIC SYMPTOMS ; HIGH-RISK ; METAANALYSIS ; PREVALENCE ; IMPACT ; PSYCHOPATHOLOGY ; INDIVIDUALS ; ASSOCIATION ; ADVERSITIES
摘要	Rumination and childhood trauma are related to depressive symptoms in clinical and non-clinical individuals. This is the first study aimed to test the mediating effect of rumination on the relationship between childhood trauma and depressive symptoms in schizophrenia patients. A total of 313 schizophrenia patients were recruited in the present study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was adopted to evaluate depressive symptoms, the short-form Childhood Trauma Questionnaire (CTQ-SF) and the 10-item Ruminative response scale (RRS-10) were utilized to assess the childhood trauma and rumination in patients, respectively. Our results showed that 168 schizophrenia patients (53.67%) had comorbid depressive symptoms. These patients with depressive symptoms had higher levels of childhood trauma [both CTQ-SF total scores and emotional abuse (EA), emotional neglect (EN), physical neglect (PN) subscale scores] and rumination (both RRS-10 total scores and brooding, reflection subscale scores) compared to patients without depressive symptoms. The stepwise logistic regression analysis identified that EN (OR 1.196, P = 0.003), PN (OR 1.1294, P < 0.001), brooding (OR 1.291, P < 0.001) and reflection (OR 1.481, P < 0.001) could independently predict the depressive symptoms in schizophrenia patients. Moreover, RRS-10 and its subscale scores could mediate the relationship between depressive symptoms and childhood trauma, especially EA, EN and PN in schizophrenia. Our preliminary findings suggest that the rigorous assessment and psychosocial interventions of rumination are important to alleviate the influence of childhood trauma on depressive symptoms in schizophrenia patients.
资助项目	National Key Research and Development Program of China; National Natural Science Foundation of China [2018YFC1314302, 2018YFC1314300, 2016YFC1307002]; Medical Science and Technology Development Foundation [81771450, 81471358, 81971255, 81571314]; Nanjing Department of Health; Science and Technology Development Program of Nanjing Medical University [YKK20090]; [NMUB2019107]
出版者	SPRINGER HEIDELBERG
出版地	HEIDELBERG
ISSN	0940-1334
EISSN	1433-8491
卷号	273 期号:5 页码:1085-1094
DOI	10.1007/s00406-022-01525-2
页数	10
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000896448000002
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2022-12
URL	查看原文
PubMed ID	36484845
SCOPUSEID	2-s2.0-85143516159
通讯作者地址	[Zhang, Xiangrong]Department of Geriatric Psychiatry,The Affiliated Brain Hospital of Nanjing Medical University,Nanjing,China ; [Zhang, Chen]Schizophrenia Program,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Scopus学科分类	Psychiatry and Mental Health;Biological Psychiatry;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172267
专题	其他_附属康宁医院（温州市康宁医院）第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Zhang, Xiangrong; Zhang, Chen
作者单位	1.Department of Geriatric Psychiatry,The Affiliated Brain Hospital of Nanjing Medical University,Nanjing,China; 2.Schizophrenia Program,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 3.Department of Psychiatry,The Second People’s Hospital of Jiangning District,Nanjing,China; 4.The Affiliated Kangning Hospital of Wenzhou Medical University,Wenzhou,China; 5.Department of Psychiatry,School of Mental Health,Wenzhou Medical University,Wenzhou,China; 6.Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
推荐引用方式 GB/T 7714	Fang, Xinyu,Wu, Zenan,Wen, Lu,et al. Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023,273(5):1085-1094.
APA	Fang, Xinyu., Wu, Zenan., Wen, Lu., Zhang, Yaoyao., Wang, Dandan., ... & Zhang, Chen. (2023). Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 273(5), 1085-1094.
MLA	Fang, Xinyu,et al."Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 273.5(2023):1085-1094.