Clinical significance of intrarenal vascular lesions in non-hypertensive patients with IgA nephropathy

doi:10.1007/s40620-022-01511-w

科研成果详情

题名	Clinical significance of intrarenal vascular lesions in non-hypertensive patients with IgA nephropathy
作者	Huang, Ziyuan1,2; Hu, Ya1,2; Chen, Bo 1,2; Liang, Yan1,2; Li, Duo 1,2; Qiu, Wenxian1,2; Zhang, Ji1,2; Chen, Chaosheng1,2
发表日期	2022-12-01
发表期刊	JOURNAL OF NEPHROLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Chronic Kidney diseases Clinicopathology IgA nephropathy Intrarenal vascular lesions Prognosis
其他关键词	ARTERIOLAR HYALINOSIS ; OXFORD CLASSIFICATION ; BLOOD-PRESSURE ; HYPERTENSION
摘要	Background The clinical significance of intrarenal vascular lesions has not been elucidated in primary IgA nephropathy (IgAN), especially in non-hypertensive subjects. Methods From January 2003 to December 2020, data of 3435 patients with biopsy-proven IgAN were reviewed. Two hundred-forty non-hypertensive patients who met the criteria for IgAN and had intrarenal vascular lesions (IgAN-vas) were selected. The control cohort was constructed with 1:1 matched cases of non-hypertensive IgAN patients without vascular lesions according to age, gender, estimated glomerular filtration rate (eGFR) and follow-up time. Results The IgAN-vas cohort had significantly higher serum uric acid levels than the control IgAN cohort (P < 0.05); glomerulosclerosis was more common in IgAN-vas patients. Moreover, cluster analysis indicated that the serum uric acid level was associated with serum creatinine (s-Cr) levels in IgAN-vas while it was associated with serum lactate dehydrogenase (LDH) levels in control cases with IgAN. Both Kaplan-Meier analysis and generalized linear mixed-effects models revealed that the prognosis of the IgAN-vas cohort was significantly worse than that of the IgAN cohort after > 5 years of follow-up. Intimal thickening was an independent risk factor associated with reaching the endpoint (eGFR decrease >= 30% from the baseline or reaching end-stage renal disease [ESRD] or death). Conclusions The prognosis of non-hypertensive patients with IgAN-vas was worse than that of matched individuals with IgAN. The clinicopathologic manifestation of IgAN-vas was more severe, and included a higher proportion of glomerulosclerosis, and a higher serum uric acid level correlated with renal function impairment. [GRAPHICS] .
资助项目	Natural Science Foundation of Zhejiang Province; [LY22H050004]
出版者	SPRINGER HEIDELBERG
出版地	HEIDELBERG
ISSN	1121-8428
EISSN	1724-6059
DOI	10.1007/s40620-022-01511-w
页数	12
WOS类目	Urology & Nephrology
WOS研究方向	Urology & Nephrology
WOS记录号	WOS:000901698200001
收录类别	SCIE
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172077
专题	附属第一医院_肾内科温州医科大学
通讯作者	Zhang, Ji; Chen, Chaosheng
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nephrol, Nanbaixiang, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Inst Chron Kidney Dis, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院_肾内科; 温州医科大学
第一作者的第一单位	附属第一医院_肾内科
推荐引用方式 GB/T 7714	Huang, Ziyuan,Hu, Ya,Chen, Bo,et al. Clinical significance of intrarenal vascular lesions in non-hypertensive patients with IgA nephropathy[J]. JOURNAL OF NEPHROLOGY,2022.
APA	Huang, Ziyuan., Hu, Ya., Chen, Bo., Liang, Yan., Li, Duo., ... & Chen, Chaosheng. (2022). Clinical significance of intrarenal vascular lesions in non-hypertensive patients with IgA nephropathy. JOURNAL OF NEPHROLOGY.
MLA	Huang, Ziyuan,et al."Clinical significance of intrarenal vascular lesions in non-hypertensive patients with IgA nephropathy".JOURNAL OF NEPHROLOGY (2022).