Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress

doi:10.1080/13880209.2022.2157021

科研成果详情

题名	Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress
作者	Tian, Qingxin 1; Liu, Jianlong 1; Chen, Qin2; Zhang, Mingxiao1
发表日期	2023-12-31
发表期刊	PHARMACEUTICAL BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Transverse aortic constriction angiotensin II heart failure pressure overload cardiac fibrosis
其他关键词	HEART-FAILURE ; ER STRESS ; IN-VIVO ; LACTONE
摘要	Context Andrographolide (Andr) is a bioactive Andr diterpenoid extracted from herbaceous Andrographis paniculata (Burm. F.) Wall. ex Nees (Acanthaceae). Andr can relieve cardiac dysfunction in mice by inhibiting the mitogen-activated protein kinases (MAPK) pathway. Objective This study investigates the efficacy and underlying mechanism of Andr on cardiac hypertrophy in mice. Materials and methods Male C57 mice (20-25 g, 6-8 weeks) were divided into four groups (n = 10 mice/group) as sham group (sham operation), transverse aortic constriction (TAC) model group, TAC + Andr 100 mg/kg group and TAC + Andr 200 mg/kg group. Andr groups were given intragastric administration of Andr (100 and 200 mg/kg) once a day for 14 consecutive days. An in vitro hypertrophy model was established by adding 1 mu M of Ang II to H9c2 cells for 48 h induction. Results In TAC-mice, Andr improved echocardiographic indices [reduced LVESD (30.4% or 37.1%) and LVEDD (24.8% or 26.4%), increased EF (22.9% or 42.6%) and FS (25.4% or 52.2%)], reduced BNP (11.5% or 23.6%) and Ang II levels (10.3% or 32.8%), attenuates cardiac fibrosis and reduces cardiac cell apoptosis in TAC mice. In vitro, Andr attenuated cardiomyocyte hypertrophy and decreased the protein expression of GRP78 (67.8%), GRP94 (47.6%), p-PERK (44.9%) and CHOP (66.8%) in Ang-II-induced H9c2 cells and reversed after endoplasmic reticulum (ER) stress agonist Tunicamycin (TN) treatment. Discussion and conclusions Andr was found to be an anti-hypertrophic regulator, which could attenuate cardiac hypertrophy by suppressing ER stress. It may be a new therapeutic drug for cardiac hypertrophy.
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1388-0209
EISSN	1744-5116
卷号	61 期号:1 页码:61-68
DOI	10.1080/13880209.2022.2157021
页数	8
WOS类目	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS记录号	WOS:000902414300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	36548192
SCOPUSEID	2-s2.0-85144512150
通讯作者地址	[Zhang, Mingxiao]Department of Anesthesiology,the First Affiliated Hospital of Wenzhou Medical University,Shangcai Village, Nanbaixiang Street, Ouhai District, Zhejiang,Wenzhou,325000,China
Scopus学科分类	Molecular Medicine;Pharmacology;Pharmaceutical Science;Drug Discovery;Complementary and Alternative Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172071
专题	附属第一医院_麻醉科
通讯作者	Zhang, Mingxiao
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Tian, Qingxin,Liu, Jianlong,Chen, Qin,et al. Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress[J]. PHARMACEUTICAL BIOLOGY,2023,61(1):61-68.
APA	Tian, Qingxin, Liu, Jianlong, Chen, Qin, & Zhang, Mingxiao. (2023). Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress. PHARMACEUTICAL BIOLOGY, 61(1), 61-68.
MLA	Tian, Qingxin,et al."Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress".PHARMACEUTICAL BIOLOGY 61.1(2023):61-68.