Analysis of the incidence and influencing factors associated with binary restenosis of target lesions after drug-coated balloon angioplasty for patients with in-stent restenosis

doi:10.1186/s12872-022-02923-z

科研成果详情

题名	Analysis of the incidence and influencing factors associated with binary restenosis of target lesions after drug-coated balloon angioplasty for patients with in-stent restenosis
作者	Xue, Weihao; Ma, Jun; Yu, Xiaojie; Ruan, Zhisheng; Sun, Yuanxue; Wu, Tianbo; Zhang, Xinmin; Wu, Lianpin
发表日期	2022-11-20
发表期刊	BMC CARDIOVASCULAR DISORDERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Coronary artery disease Drug-coated balloon In-stent restenosis Influencing factors
其他关键词	PERCUTANEOUS CORONARY INTERVENTION ; ELUTING STENTS ; DISEASE ; TRIAL
摘要	Background Drug-coated balloon (DCB) is a novel and effective device for coronary artery disease patients with in-stent restenosis (ISR). However, the incidence and possible influencing factors associated with binary restenosis have not yet been adequately assessed. Methods The data are extracted from a prospective, multicenter, randomized controlled trial. A total of 211 patients with ISR were enrolled at 13 centers from August 2017 to October 2018 and treated with DCB. At the 9-month coronary angiographic follow-up, patients were divided into restenosis and non-restenosis groups, and demographic data, lesion features, and laboratory tests were retrospectively reviewed. Furthermore, logistic regression analysis was used to identify possible influencing factors. Results All patients successfully underwent treatment, and 166 patients with 190 lesions took part in angiography follow-ups at 9 months. Of these, 41 patients with 44 target lesions developed restenosis following treatment, and the incidence of ISR was 24.7%. There were significant differences in the average length of target lesions and the number of multivessel lesions and fasting plasma glucose (FBG) between the two groups (p < 0.05). Demographic data, cardiac risk factors, left ventricular ejection fractions (LVEF), blood routine tests, biochemical tests, and other features of devices and lesions showed no difference. Logistic regression analyses showed that FBG > 6.1 mmol/L (OR: 7.185 95% CI: 2.939-17.567 P < 0.001) and length of lesion (OR:1.046 95% CI: 1.001-1.093 P = 0.046) were associated risk factors. Conclusions The longer length of lesions, more target lesions and FBG > 6.1 mmol/L per individual may be characteristics of patients showing ISR following treatment. Studies with larger sample size, and more complete follow-up data are needed in the future to expend on these findings.
资助项目	National Natural Science Foundation of China [82170265]
出版者	BMC
出版地	LONDON
ISSN	1471-2261
卷号	22 期号:1
DOI	10.1186/s12872-022-02923-z
页数	8
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:000885838100004
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	36404303
SCOPUSEID	2-s2.0-85142270932
通讯作者地址	[Zhang, Xinmin]Department of Cardiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China ; [Wu, Lianpin]Department of Cardiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Cardiology and Cardiovascular Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/171613
专题	第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Zhang, Xinmin; Wu, Lianpin
作者单位	Department of Cardiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Xue, Weihao,Ma, Jun,Yu, Xiaojie,et al. Analysis of the incidence and influencing factors associated with binary restenosis of target lesions after drug-coated balloon angioplasty for patients with in-stent restenosis[J]. BMC CARDIOVASCULAR DISORDERS,2022,22(1).
APA	Xue, Weihao., Ma, Jun., Yu, Xiaojie., Ruan, Zhisheng., Sun, Yuanxue., ... & Wu, Lianpin. (2022). Analysis of the incidence and influencing factors associated with binary restenosis of target lesions after drug-coated balloon angioplasty for patients with in-stent restenosis. BMC CARDIOVASCULAR DISORDERS, 22(1).
MLA	Xue, Weihao,et al."Analysis of the incidence and influencing factors associated with binary restenosis of target lesions after drug-coated balloon angioplasty for patients with in-stent restenosis".BMC CARDIOVASCULAR DISORDERS 22.1(2022).