Association of Polymorphisms in the Platelet Receptor Gene(P2Y12, P2Y1) and Platelet Glycoprotein Gene(GPIIIa) with Response to Antiplatelet Drug and Clinical Outcomes after Acute Minor Ischemic Stroke Genetic determinants of response to antiplatelet drugs

科研成果详情

题名	Association of Polymorphisms in the Platelet Receptor Gene(P2Y12, P2Y1) and Platelet Glycoprotein Gene(GPIIIa) with Response to Antiplatelet Drug and Clinical Outcomes after Acute Minor Ischemic Stroke Genetic determinants of response to antiplatelet drugs
作者	Xingyang Yi ; Qiang Zhou ; Chun Wang ; Jing Lin ; Ping Liu ; Cheng Fu
发表日期	2016-05-26
会议录名称	四川省医学会第十五次精神病学学术会议暨第三次心身医学学术会议论文汇编集影响因子和分区
语种	英语
原始文献类型	中国会议
摘要	Objective: Patients with minor ischemic stroke(MIS) are at a high risk of recurrent ischemic stroke(RIS).However,few studies to investigated the effects of gene variants on antiplatelet drug responsiveness in MIS.The aim of this study was to investigate the association of platelet receptor gene(P2Y12, P2Y1) and glycoprotein gene(GPIIIa) variants, as well as their interactions with antiplatelet drugs responsiveness and clinical outcomes in acute MIS. Methods: We prospective consecutively enrolled 426 patients with acute MIS who were receiving combined treatment of aspirin and clopidogrel for at least 3 months.The seven variants from P2Y12, P2Y1 and GPIIIa genes were examined using mass spectrometry. Gene-gene interactions were analyzed using generalized multifactor dimensionality reduction(GMDR) analysis. Antiplatelet drugs responsiveness was assessed by platelet aggregation assay.All patients were followed up for 90 days. Primary outcomes were evaluated as a composite of RIS, myocardial infarction(MI) and death. Results: Among the 426 patients, the primary adverse events occurred in 46(10.8%) patients(40 had RIS, 2 died, and 6 had MI) during the first 90 days after stroke. There were no significant differences in the frequencies of the genotypes of the seven variants between the patients with and without adverse events using single-locus analytical approach. However, there was significant gene-gene interaction between rs16863323 and rs2317676. The high-risk interactive genotypes were independently associated with antiplatelet drug responsiveness and clinical outcomes. Conclusion: Sensitivity of MIS patients to antiplatelet drugs and adverse clinical events maybe multifactorial, but is not determined by single gene polymorphisms.
页码	24
收录类别	CNKI
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167945
专题	其他_附属第三医院（瑞安市人民医院）
作者单位	1.Department of Neurology 2.People's Hospital of Deyang City 3.Department of Neurology 4.Third Affiliated Hospital of Wenzhou Medical College
推荐引用方式 GB/T 7714	Xingyang Yi,Qiang Zhou,Chun Wang,et al. Association of Polymorphisms in the Platelet Receptor Gene(P2Y12, P2Y1) and Platelet Glycoprotein Gene(GPIIIa) with Response to Antiplatelet Drug and Clinical Outcomes after Acute Minor Ischemic Stroke Genetic determinants of response to antiplatelet drugs[C],2016:24.