Salvianolic acid A protects myocardial ischemia/reperfusion injury via reducing platelet activation and inflammation

科研成果详情

题名	Salvianolic acid A protects myocardial ischemia/reperfusion injury via reducing platelet activation and inflammation
作者	Yuan xiaolin ; Zhu ni ; Zhao xuyong ; Xiang yijia ; Ye shiyong ; Zhong Peng ; Zeng chunlai
发表日期	2015-06-25
会议录名称	2015年浙江省心电生理与起搏学术年会论文汇编影响因子和分区
语种	英语
原始文献类型	中国会议
摘要	Objective To investigate the protective effect of Salvianolic acid A(SAA) on myocardial ischemia / reperfusion injury.Methods Male SD rats were subjected ischemia for 45 minutes by ligation of coronary artery to establish acute myocardial ischemia/reperfusion models.SAA(10mg/kg) or tirofiban(60ug/kg) was given by jugular vein injection 10 min before reperfusion.After reperfusion for 3 hours,the level of platelet aggregation was measured using an aggregometer and the content of nitric oxide(NO) was detected by ultraviolet spectrop hotometer.Serum levels of p-selectin,cardiac troponin T(cTnT),creatine kinase isoenzyme MB(CK-MB),inflammatory cytokine interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α) were measured at 3 hours and 24 hours after reperfusion.Histopathological analysis of ischemic myocardial morphology was determined on hematoxylin-eosin and the area of infracted area was evaluated by evans blue and triphenyltetra zolium chloride staining.Result:Treatment of SAA increased survival rate following myocardial Ischemia/Reperfusion,relieved myocardial cell damage and inflammation,decreased myocardial infarct size,inhibited platelet aggregation,reduced the serum levels of p-Selectin,TNF-α,IL-1β,cTnT and CK-MB,enhanced nitric oxide concentration of myocardial tissue.Conclusions:SAA has protective effects on myocardial ischemia / reperfusion injury by means of antiplatelet and anti-inflammation
页码	1
收录类别	CNKI
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167881
专题	其他_附属第五医院（丽水市中心医院）
作者单位	1.Department of cardiology 2.the fifth affiliated hospital of Wenzhou medical University
推荐引用方式 GB/T 7714	Yuan xiaolin,Zhu ni,Zhao xuyong,et al. Salvianolic acid A protects myocardial ischemia/reperfusion injury via reducing platelet activation and inflammation[C],2015:1.