Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice

doi:10.1016/j.jff.2022.105179

科研成果详情

题名	Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice
作者	Chen, Cong-Cong 1; Wang, Yi-Hong2; Sun, Rong-Yue2; Lu, Xin-Yu 3; Xu, Yu-Peng 3; Wang, Yong-qiang4; Li, Jiang-Yuan 3; Wang, Hong-Wei 4; Chen, Ke-Wei5
发表日期	2022-09
发表期刊	JOURNAL OF FUNCTIONAL FOODS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Salidroside Severe acute pancreatitis Nrf2 NF-?B
其他关键词	REVISED ATLANTA CLASSIFICATION ; NF-KAPPA-B ; TISSUE-DAMAGE ; INJURY ; INHIBITION ; ACTIVATION ; RECRUITMENT ; NECROSIS ; RATS
摘要	Severe acute pancreatitis (SAP) is a fatal inflammation with no effective treatment. Salidroside, a monomer isolated from the traditional Chinese medicine Rhodiola, has been shown cytoprotective roles in many inflammation-related diseases. However, whether salidroside plays a protective role in an acute inflammation like SAP in mice is unknown. In this study, we aimed to investigate the molecular mechanism underlying the pancreatic protection of salidroside. The results showed that salidroside attenuated caerulein with the LPS-induced pancreatic injury in a mouse model of SAP. Also, we found that salidroside ameliorated oxidative stress and inflammation responses in SAP mice. Furthermore, SAP mice treated with salidroside were associated with higher phosphorylation levels of Nrf2 and less nuclear accumulation of NF-kappa B p65. We further found that depletion of Nrf2 weakened the protective effect of salidroside in SAP mice. Collectively, salidroside mediated anti-oxidant stress and anti-inflammation in SAP mice partially through the Nrf2/NF-kappa B p65 pathway.
资助项目	Wenzhou Science and Technology bureau [Y20210132]; Research Incubation Project of The First Affiliated Hospital of Wenzhou Medical University [FHY2019058]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	1756-4646
EISSN	2214-9414
卷号	96
DOI	10.1016/j.jff.2022.105179
页数	11
WOS类目	Food Science & Technology ; Nutrition & Dietetics
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000862694200004
收录类别	SCIE
通讯作者地址	[Wang, Hong-Wei]Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China. ; [Chen, Ke-Wei]Wenzhou Med Univ, Dept Plast Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
TOP期刊	TOP期刊
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167221
专题	附属第一医院_儿科第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
通讯作者	Wang, Hong-Wei; Chen, Ke-Wei
作者单位	1.Zhejiang Univ, Affiliated Jinhua Hosp, Dept Pharm, Sch Med, Jinhua, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Pediat, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Dept Plast Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室; 第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
推荐引用方式 GB/T 7714	Chen, Cong-Cong,Wang, Yi-Hong,Sun, Rong-Yue,et al. Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice[J]. JOURNAL OF FUNCTIONAL FOODS,2022,96.
APA	Chen, Cong-Cong., Wang, Yi-Hong., Sun, Rong-Yue., Lu, Xin-Yu., Xu, Yu-Peng., ... & Chen, Ke-Wei. (2022). Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice. JOURNAL OF FUNCTIONAL FOODS, 96.
MLA	Chen, Cong-Cong,et al."Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice".JOURNAL OF FUNCTIONAL FOODS 96(2022).