Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma.

doi:10.1136/jcp-2021-207795

科研成果详情

题名	Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma.
作者	Chen, Xiaohu1; Chen, Hanbin 2; Lin, Rixu1; Li, Yulian1; Guo, Ying1; Chen, Qi1; Zhang, Yanyan 1; Cai, Guoping 3; Hu, Mengjun 4; Chen, Guorong1
发表日期	2022-11-01
发表期刊	Journal of clinical pathology 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Immunoglobulins LYMPHOCYTES Pathology, Surgical Urinary Bladder
其他关键词	POOR-PROGNOSIS ; B7-H1 PD-L1 ; T-CELLS ; CANCER ; MICROENVIRONMENT ; ACTIVATION ; DENSITY ; GRADE
摘要	Programmed cell death-ligand 1 (PD-L1) as a cell surface glycoprotein can inhibit T cell function when binding to its receptor, PD-1. The newly developed therapy of targeting PD-1/PD-L1 signal pathway has shown great promise for the treatment of non-small cell lung cancer as well as melanoma. Approved by Food and Drug Administration, atezolizumab has become the first new drug to treat advanced bladder cancer. The aim of this study is to evaluate whether PD-L1 is associated with the lymphocytes infiltration in the tumour microenvironment and to assess the prognostic value of PD-L1 expression., Among 96 invasive bladder urothelial carcinomas, some were used to construct tissue-microarrays, and some cases with shallow infiltration or large heterogeneity were performed, respectively, for the following work. By means of immunohistochemistry and HE, PD-L1 expression and immune cell infiltration in the invasive front of urothelial carcinoma were analysed., We find that PD-L1 expression in tumour cells and lymphocytes are significantly associated with more tumour infiltrating lymphocytes (TILs) and more T cells. The integrated TILs, T-PD-L1 and I-PD-L1 are not significantly correlated with the overall survival (OS) of patients. However, the combination of T-PD-L1 and TILs, T-PD-L1 and I-PD-L1 is significantly correlated with the OS of patients. The T-PD-L1 (-)/TIL (-) group show the best prognosis and the T-PD-L1 (+)/I-PD-L1 (-) group show the worst prognosis. Furthermore, a multivariate analysis reveal that PD-L1 expression of lymphocytes is an independent prognostic factor for OS of patients., Our study reveal that PD-L1 of tumour cells are associated with the corresponding T cells infiltration and that the combination of T-PD-L1 and I-PD-L1, T-PD-L1 and TILs could be a relevant marker for the determination of the prognostic role of patients with the urothelial carcinoma.
资助项目	Study of GM-CSF/IL2- surface-modified autologous whole cell vaccine for the advanced bladder cancer [WKJ-ZJ-1929]
出版者	BMJ PUBLISHING GROUP
ISSN	0021-9746
EISSN	1472-4146
卷号	77 期号:1 页码:61-67
DOI	10.1136/jcp-2021-207795
页数	7
WOS类目	Pathology
WOS研究方向	Pathology
WOS记录号	WOS:000880046600001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36319076
SCOPUSEID	2-s2.0-85142310396
通讯作者地址	[Chen, Guorong]Department of Pathology,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Hu, Mengjun]Department of Pathology,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Pathology and Forensic Medicine
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167079
专题	附属第一医院其他_附属诸暨医院（诸暨市人民医院）
通讯作者	Hu, Mengjun; Chen, Guorong
作者单位	1.Department of Pathology,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Oncology,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Pathology,Yale University,Center for Medical Informatics,New Haven,United States; 4.Department of Pathology,Zhuji Affiliated Hospital,Wenzhou Medical University,Zhejiang,Zhuji,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xiaohu,Chen, Hanbin,Lin, Rixu,et al. Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma.[J]. Journal of clinical pathology,2022,77(1):61-67.
APA	Chen, Xiaohu., Chen, Hanbin., Lin, Rixu., Li, Yulian., Guo, Ying., ... & Chen, Guorong. (2022). Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma.. Journal of clinical pathology, 77(1), 61-67.
MLA	Chen, Xiaohu,et al."Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma.".Journal of clinical pathology 77.1(2022):61-67.