Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.

doi:10.3389/fpsyt.2022.1017888

科研成果详情

题名	Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.
作者	Su, Liming 1; Shuai, Yibing 1; Mou, Shaoqi2; Shen, Yue 1; Shen, Xinhua 1; Shen, Zhongxia 1; Zhang, Xiaomei 1
发表日期	2022-10-06
发表期刊	Frontiers in psychiatry 影响因子和分区
语种	英语
原始文献类型	Article
关键词	bipolar depression (BD) differential diagnosis lymphocyte subsets major depressive disorder (MDD) nomogram
其他关键词	REGULATORY T-CELLS ; GENE-EXPRESSION ; B-CELLS ; INTERNATIONAL SOCIETY ; CLINICAL-FEATURES ; IMMUNE ACTIVATION ; ONSET ; AGE ; ANXIETY ; MOOD
摘要	Bipolar depression (BD) and major depressive disorder (MDD) are both common affective disorders. The common depression episodes make it difficult to distinguish between them, even for experienced clinicians. Failure to properly diagnose them in a timely manner leads to inappropriate treatment strategies. Therefore, it is important to distinguish between BD and MDD. The aim of this study was to develop and validate a nomogram model that distinguishes BD from MDD based on the characteristics of lymphocyte subsets., A prospective cross-sectional study was performed. Blood samples were obtained from participants who met the inclusion criteria. The least absolute shrinkage and selection operator (LASSO) regression model was used for factor selection. A differential diagnosis nomogram for BD and MDD was developed using multivariable logistic regression and the area under the curve (AUC) with 95% confidence interval (CI) was calculated, as well as the internal validation using a bootstrap algorithm with 1,000 repetitions. Calibration curve and decision curve analysis (DCA) were used to evaluate the calibration and clinical utility of the nomogram, respectively., {AbstractText=A total of 166 participants who were diagnosed with BD (83 cases) or MDD (83 cases), as well as 101 healthy controls (HCs) between June 2018 and January 2022 were enrolled in this study. CD19+ B cells, CD3+ T cells, CD3-CD16/56+ NK cells, and total lymphocyte counts were strong predictors of the diagnosis of BD and MDD and were included in the differential diagnosis nomogram. The AUC of the nomogram and internal validation were 0.922 (95%; CI, 0.879-0.965), and 0.911 (95% CI, 0.838-0.844), respectively. The calibration curve used to discriminate BD from MDD showed optimal agreement between the nomogram and the actual diagnosis. The results of DCA showed that the net clinical benefit was significant.}, This is an easy-to-use, repeatable, and economical nomogram for differential diagnosis that can help clinicians in the individual diagnosis of BD and MDD patients, reduce the risk of misdiagnosis, facilitate the formulation of appropriate treatment strategies and intervention plans.
资助项目	Huzhou Public Welfare Research Project Social Development Category; Social Development Project of Public Welfare Technology Application in Zhejiang Province; [2018GYB49]; [LGF19H090002]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-0640
卷号	13 页码:1017888
DOI	10.3389/fpsyt.2022.1017888
页数	12
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:000873754300001
收录类别	PUBMED ; SCIE ; SCOPUS ; SSCI
URL	查看原文
PubMed ID	36276314
SCOPUSEID	2-s2.0-85140470660
社科自定义期刊分类	E类
通讯作者地址	[Shen, Zhongxia]Department of Neurosis and Psychosomatic Diseases,Huzhou Third Municipal Hospital,The Affiliated Hospital of Huzhou University,Huzhou,China ; [Zhang, Xiaomei]Department of Neurosis and Psychosomatic Diseases,Huzhou Third Municipal Hospital,The Affiliated Hospital of Huzhou University,Huzhou,China
Scopus学科分类	Psychiatry and Mental Health
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166995
专题	第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Shen, Zhongxia; Zhang, Xiaomei
作者单位	1.Department of Neurosis and Psychosomatic Diseases,Huzhou Third Municipal Hospital,The Affiliated Hospital of Huzhou University,Huzhou,China; 2.Department of Psychiatry,Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Su, Liming,Shuai, Yibing,Mou, Shaoqi,et al. Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.[J]. Frontiers in psychiatry,2022,13:1017888.
APA	Su, Liming., Shuai, Yibing., Mou, Shaoqi., Shen, Yue., Shen, Xinhua., ... & Zhang, Xiaomei. (2022). Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.. Frontiers in psychiatry, 13, 1017888.
MLA	Su, Liming,et al."Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.".Frontiers in psychiatry 13(2022):1017888.