Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish

doi:10.1016/j.chemosphere.2016.11.089

科研成果详情

题名	Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish
作者	Chen, Jiangfei1; Saili, Katerine S.2; Liu, Yueqin 1; Li, Lelin 1; Zhao, Yuxin 1; Jia, Yinhang 1; Bai, Chenglian1; Tanguay, Robert L.2; Dong, Qiaoxiang1; Huang, Changjiang 1
发表日期	2017-02
发表期刊	CHEMOSPHERE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Zebrafish Bisphenol A Procreation ability Sperm motility Reproduction Chronic exposure
其他关键词	ENDOCRINE-DISRUPTING CHEMICALS ; ENVIRONMENTALLY RELEVANT CONCENTRATIONS ; TROUT ONCORHYNCHUS-MYKISS ; MEDAKA ORYZIAS-LATIPES ; DANIO-RERIO ; XENOPUS-LAEVIS ; ESTROGENIC RESPONSE ; GONAD DEVELOPMENT ; MALE GOLDFISH ; MALE RATS
摘要	The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included FO adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups. Testis weight was decreased only following the 6 hpf to 5 mpf 0.001 mu M BPA exposure. The lowest effect level indicated by a reduction in sperm volume, density, motility, and velocity across a range of exposure durations was 0.001 mu M, with all but sperm density significant for the longest exposure duration, which was also the only significant endpoint for the lowest exposure concentration in the 3-5 mpf exposure group. Nonmonotonic concentration-response curves were noted for all F0 reproductive endpoints for at least one of the two longest exposure durations. For the F1 offspring of fish exposed from 6 hpf to 5 mpf, malformations and mortality were increased following 0.001 mu M BPA exposure, while egg production and fertilization were reduced in higher concentration treatment groups. Overall, BPA exposure during three different developmental periods impaired zebrafish reproductive development, with most significance changes found in the lowest concentration treatment groups. Genetic impacts on gamete development may underlie the secondary effects of reduced fertilization rate, embryonic mortality, and malformations. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41271491, 21307096]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R21ES018970, P30 85000210]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0045-6535
EISSN	1879-1298
卷号	169 页码:262-270
DOI	10.1016/j.chemosphere.2016.11.089
页数	65
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
WOS记录号	WOS:000393003300032
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20164803049385
EI主题词	Cell proliferation
URL	查看原文
PubMed ID	27880925
SCOPUSEID	2-s2.0-84995934699
通讯作者地址	[Huang, Changjiang]Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Environmental Engineering;Environmental Chemistry;Chemistry (all);Pollution;Health, Toxicology and Mutagenesis
TOP期刊	TOP期刊
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16677
专题	公共卫生学院_健康与环境生态研究所公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Huang, Changjiang
作者单位	1.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Environmental and Molecular Toxicology,The Sinnhuber Aquatic Research Laboratory,the Environmental Health Sciences Center,Oregon State University,Corvallis,97333,United States
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Chen, Jiangfei,Saili, Katerine S.,Liu, Yueqin,et al. Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish[J]. CHEMOSPHERE,2017,169:262-270.
APA	Chen, Jiangfei., Saili, Katerine S.., Liu, Yueqin., Li, Lelin., Zhao, Yuxin., ... & Huang, Changjiang. (2017). Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish. CHEMOSPHERE, 169, 262-270.
MLA	Chen, Jiangfei,et al."Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish".CHEMOSPHERE 169(2017):262-270.