Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm

doi:10.1021/acsnano.7b04731

科研成果详情

题名	Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm
作者	Hu, Dengfeng 1; Li, Huan 1; Wang, Bailiang2; Ye, Zi2; Lei, Wenxi 1; Jia, Fan 1; Jin, Qiao 1; Ren, Ke-Feng 1; Ji, Jian 1
发表期刊	ACS NANO 影响因子和分区
语种	英语
原始文献类型	Article
关键词	biofilm gold nanoparticles mixed charged zwitterion pH-responsive photothermal therapy
其他关键词	ANTIMICROBIAL ACTIVITIES ; ANTIBACTERIAL MATERIALS ; ANTIBIOTIC-RESISTANCE ; BACTERIAL BIOFILMS ; CANDIDA-ALBICANS ; IN-VITRO ; POLYMERS ; AGENTS ; NANOCOMPOSITES ; EFFICIENCY
摘要	Biofilms that contribute to the persistent bacterial infections pose serious threats to global public health, mainly due to their resistance to antibiotics penetration and escaping innate immune attacks by phagocytes. Here, we report a kind of surface-adaptive gold nanoparticles (AuNPs) exhibiting (1) a self-adaptive target to the acidic microenvironment of biofihn, (2) an enhanced photothermal ablation of methicillin-resistant Staphylococcus aureus (MRSA) biofilm under near-infrared (NIR) light irradiation, NIR AuNPs Injection NIR Irradiation and (3) no damage to the healthy tissues around the biofilm. Originally, AuNPs were readily prepared by surface modification with pH-responsive mixed charged zwitterionic self-assembled monolayers consisting of weak electrolytic 11-mercaptoundecanoic acid (HS-C10-COOH) and strong electrolytic (10-mercaptodecyl)trimethylammonium bromide (HS-C-30-N-4). The mixed charged zwitterion-modified AuNPs showed fast pH-responsive transition from negative charge to positive charge, which enabled the AuNPs to disperse well in healthy tissues (pH similar to 7.4), while quickly presenting strong adherence to negatively charged bacteria surfaces in MRSA biofilm (pH similar to 5.5). Simultaneous AuNP aggregation within the MRSA biofilm enhanced the photothermal ablation of MRSA biofilm under NIR light irradiation. The surrounding healthy tissues showed no damage because the dispersed AuNPs had no photothermal effect under NIR light. In view of the above advantages as well as the straightforward preparation, AuNPs developed in this work may find potential applications as a useful antibacterial agent in the areas of healthcare.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21574114, 51573160]; Science and Technology Planning Project of Zhejiang Province [2016C04002, 2016C54003]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	1936-0851
EISSN	1936-086X
卷号	11 期号:9 页码:9330-9339
DOI	10.1021/acsnano.7b04731
页数	57
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000411918200084
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
发表日期	2017-09
EI入藏号	20174004221552
EI主题词	Biofilms
URL	查看原文
Pubmed记录号	28806528
Scopus记录号	2-s2.0-85029925321
ESI高被引论文	2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
自科自定义期刊分类	T3(B)类
引用统计	被引频次：338[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16674
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Ji, Jian
作者单位	1.Zhejiang Univ, Dept Polymer Sci & Engn, Minist Educ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China; 2.Wenzhou Med Univ, Hosp Eye, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China
推荐引用方式 GB/T 7714	Hu, Dengfeng,Li, Huan,Wang, Bailiang,et al. Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm[J]. ACS NANO,2017,11(9):9330-9339.
APA	Hu, Dengfeng., Li, Huan., Wang, Bailiang., Ye, Zi., Lei, Wenxi., ... & Ji, Jian. (2017). Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm. ACS NANO, 11(9), 9330-9339.
MLA	Hu, Dengfeng,et al."Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm".ACS NANO 11.9(2017):9330-9339.