Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice

doi:10.4103/1673-5374.350203

科研成果详情

题名	Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice
作者	Li, Lu-Yao1,2; Wang, Qi2; Deng, Lu 3; Lin, Zhen 4; Lin, Jing-Jing5; Wang, Xin-Ye 2; Shen, Tian-Yang 2; Zheng, Yi-Hui2; Lin, Wei 2; Li, Pei-Jun3; Fu, Xiao-Qin2; Lin, Zhen-Lang2
发表日期	2023-03
发表期刊	中国神经再生研究（英文版）影响因子和分区
语种	英语
原始文献类型	Periodical ; Article
关键词	chlorogenic acid ferroptosis glutathione peroxidase 4 lipid peroxidation neonatal hypoxic-ischemic brain injury neurons neuroprotection oxidative stress oxygen-glucose deprivation system Xc~– system Xc– system Xc
其他关键词	chlorogenic acid ; ferroptosis ; glutathione peroxidase 4 ; lipid peroxidation ; neonatal hypoxic-ischemic brain injury ; neurons ; neuroprotection ; oxidative stress ; oxygen-glucose deprivation ; system Xc-
摘要	Recent studies have shown that chlorogenic acid(CGA),which is present in coffee,has protective effects on the nervous system.However,its role in neonatal hypoxic-ischemic brain injury remains unclear.In this study,we established a newborn mouse model of hypoxic-ischemic brain injury using a modified Rice-Vannucci method and performed intraperitoneal injection of CGA.We found that CGA intervention effectively reduced the volume of cerebral infarct,alleviated cerebral edema,restored brain tissue structure after injury,and promoted axon growth in injured brain tissue.Moreover,CGA pretreatment alleviated oxygen-glucose deprivation damage of primary neurons and promoted neuron survival.In addition,changes in ferroptosis-related proteins caused by hypoxic-ischemic brain injury were partially reversed by CGA.Furthermore,CGA intervention upregulated the expression of the key ferroptosis factor glutathione peroxidase 4 and its upstream glutamate/cystine antiporter related factors SLC7A11 and SLC3A2.In summary,our findings reveal that CGA alleviates hypoxic-ischemic brain injury in neonatal mice by reducing ferroptosis,providing new ideas for the treatment of neonatal hypoxic-ischemic brain injury.
资助项目	supported by the National Natural Science Foundation of China,No.81971425;; the Natural Science Foundation of Zhejiang Province,No.LY20H040002 (both to XQF)
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
出版地	MUMBAI
ISSN	1673-5374
EISSN	1876-7958
卷号	18 期号:3 页码:568-576
DOI	10.4103/1673-5374.350203
页数	9
WOS类目	Cell Biology ; Neurosciences
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS记录号	WOS:000903720400033
收录类别	ISTIC ; CNKI ; SCIE ; PUBMED ; SCOPUS ; SCI ; 万方
URL	查看原文
PubMed ID	36018179
SCOPUSEID	2-s2.0-85137376267
通讯作者地址	[Lin, Zhen-Lang]Department of Neonatology,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China
Scopus学科分类	Developmental Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166603
专题	附属第二医院
通讯作者	Lin, Zhen-Lang
作者单位	1.Department of Pharmacy,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 2.Department of Neonatology,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 3.Department of Geriatrics,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 4.Department of Orthopedics,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 5.Department of Neurology,Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China
第一作者单位	附属第二医院
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Li, Lu-Yao,Wang, Qi,Deng, Lu,et al. Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice[J]. 中国神经再生研究（英文版）,2023,18(3):568-576.
APA	Li, Lu-Yao., Wang, Qi., Deng, Lu., Lin, Zhen., Lin, Jing-Jing., ... & Lin, Zhen-Lang. (2023). Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice. 中国神经再生研究（英文版）, 18(3), 568-576.
MLA	Li, Lu-Yao,et al."Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice".中国神经再生研究（英文版） 18.3(2023):568-576.