Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study

doi:10.1186/s12876-021-02071-2

科研成果详情

题名	Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study
作者	Shi, Yi-Yi 1; Zheng, Rui2; Cai, Jie-Jie2; Fang, Zheng-Dong 3; Chen, Wen-Jing 3; Pan, Jing-Ye2,4; Qian, Song-Zan2,4
发表日期	2021-12-20
发表期刊	BMC GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Acute kidney injury Fibrosis-4 (FIB-4) Liver fibrosis Mortality
其他关键词	FIBROSIS-4 INDEX ; MORTALITY
摘要	Background The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI. Methods We used data from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). The FIB-4 score was calculated using the existing formulas. logistic regression model, and Cox proportional hazards model were used to assessed the relationship between the FIB-4 index and in-hospital,28-day and 90-day mortality, respectively. Results A total of 3592 patients with AKI included in the data analysis. 395 (10.99%) patients died during hospitalization and 458 (12.74%) patients died in 28-day. During the 90-day follow-up, 893 (22.54%) patients were dead. An elevated FIB-4 value was significantly associated with increased in-hospital mortality when used as a continuous variable (odds ratio [OR] 1.183, 95% confidence interval [CI] 1.072-1.305, P = 0.002) and as a quartile variable (OR of Q2 to Q4 1.216-1.744, with Q1 as reference). FIB-4 was positively associated with 28-day mortality of AKI patients with hazard ratio (HR) of 1.097 (95% CI 1.008, 1.194) and 1.098 (95% 1.032, 1.167) for 90-day mortality, respectively. Conclusion This study demonstrated the FIB-4 index is associated with clinical outcomes in critically ill patients with acute kidney injury.
资助项目	Research Incubation Project of the First Affiliated Hospital of Wenzhou Medical University [FHY2019048]; Science and Technology Program of Wenzhou [Y20210713]; Ministry of Science and Technology [WKJ -ZJ-1909]; Zhejiang Province [WKJ -ZJ-1909]
出版者	BMC
出版地	LONDON
ISSN	1471-230X
EISSN	1471-230X
卷号	21 期号:1 页码:483
DOI	10.1186/s12876-021-02071-2
页数	9
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000732950500002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34930141
PMC记录号	PMC8685308
SCOPUSEID	2-s2.0-85121451996
通讯作者地址	[Pan, Jing-Ye]Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Qian, Song-Zan]Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Gastroenterology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16272
专题	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科第一临床医学院（信息与工程学院）、附属第一医院附属第一医院附属第一医院_麻醉科
通讯作者	Pan, Jing-Ye; Qian, Song-Zan
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,325000,China; 4.Wenzhou Key Laboratory of Critical Care and Artificial Intelligence,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科; 附属第一医院_麻醉科
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科; 附属第一医院_麻醉科
推荐引用方式 GB/T 7714	Shi, Yi-Yi,Zheng, Rui,Cai, Jie-Jie,et al. Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study[J]. BMC GASTROENTEROLOGY,2021,21(1):483.
APA	Shi, Yi-Yi., Zheng, Rui., Cai, Jie-Jie., Fang, Zheng-Dong., Chen, Wen-Jing., ... & Qian, Song-Zan. (2021). Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study. BMC GASTROENTEROLOGY, 21(1), 483.
MLA	Shi, Yi-Yi,et al."Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study".BMC GASTROENTEROLOGY 21.1(2021):483.