C-reactive protein-to-albumin ratio is a predictor of hepatitis B virus related decompensated cirrhosis: time-dependent receiver operating characteristics and decision curve analysis

doi:10.1097/MEG.0000000000000807

科研成果详情

题名	C-reactive protein-to-albumin ratio is a predictor of hepatitis B virus related decompensated cirrhosis: time-dependent receiver operating characteristics and decision curve analysis
作者	Huang, Si-Si 1; Xie, Dong-Mei 2; Cai, Yi-Jing3; Wu, Jian-Min4; Chen, Rui-Chong 3; Wang, Xiao-Dong 3; Song, Mei 3; Zheng, Ming-Hua3; Wang, Yu-Qun3; Lin, Zhuo3; Shi, Ke-Qing3
发表日期	2017-04
发表期刊	EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cirrhosis C-reactive protein-to-albumin ratio lymphocyte-to-monocyte ratio time-dependent decision curves time-dependent receiver operating characteristic
其他关键词	SYSTEMIC INFLAMMATORY RESPONSE ; LIVER-DISEASE SCORE ; CELL LUNG-CANCER ; PROTEIN/ALBUMIN RATIO ; LYMPHOCYTE RATIO ; PROGNOSTIC SCORE ; HEPATOCELLULAR-CARCINOMA ; INACTIVE CARRIERS ; SURFACE-ANTIGEN ; MONOCYTE RATIO
摘要	Background and aims Hepatitis B virus (HBV) infection remains a major health problem and HBV-related-decompensated cirrhosis (HBV-DC) usually leads to a poor prognosis. Our aim was to determine the utility of inflammatory biomarkers in predicting mortality of HBV-DC. Materials and methods A total of 329 HBV-DC patients were enrolled. Survival estimates for the entire study population were generated using the Kaplan-Meier method. The prognostic values for model for end-stage liver disease (MELD) score, Child-Pugh score, and inflammatory biomarkers neutrophil/lymphocyte ratio, C-reactive protein-to-albumin ratio (CAR), and lymphocyte-to-monocyte ratio (LMR) for HBV-DC were compared using time-dependent receiver operating characteristic curves and time-dependent decision curves. Results The survival time was 23.115.8 months. Multivariate analysis identified age, CAR, LMR, and platelet count as prognostic independent risk factors. Kaplan-Meier analysis indicated that CAR of at least 1.0 (hazard ratio, 7.19; 95% confidence interval, 4.69-11.03), and LMR less than 1.9 (hazard ratio, 2.40; 95% confidence interval, 1.69-3.41) were independently associated with mortality of HBV-DC. The time-dependent receiver operating characteristic indicated that CAR showed the best performance in predicting mortality of HBV-DC compared with LMR, MELD score, and Child-Pugh score. The results were also confirmed by time-dependent decision curves. Conclusion CAR and LMR were associated with the prognosis of HBV-DC. CAR was superior to LMR, MELD score, and Child-Pugh score in HBV-DC mortality prediction. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
资助项目	Scientific Research Foundation of Wenzhou, Zhejiang Province, China [Y2013073]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY16H160047]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201589, 81472651]; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0954-691X
EISSN	1473-5687
卷号	29 期号:4 页码:472-480
DOI	10.1097/MEG.0000000000000807
页数	9
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000395557800016
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	27984322
SCOPUSEID	2-s2.0-85014397117
通讯作者地址	[Shi, Ke-Qing]Department of Liver Diseases,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue lane,Wenzhou,325000,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16186
专题	附属第一医院基因组医学研究院
通讯作者	Shi, Ke-Qing
作者单位	1.Intensive Care Unit,Wenzhou Central Hospital,Zhejiang,China; 2.Department of Internal Medicine,Yongjia County Hospital of Traditional Chinese Medicine,Yongjia Branch of the First Affiliated Hospital of Wenzhou Medical University,China; 3.Department of Liver Diseases,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue lane,Wenzhou,325000,China; 4.Department of Clinical Cancer Medicine,Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Huang, Si-Si,Xie, Dong-Mei,Cai, Yi-Jing,et al. C-reactive protein-to-albumin ratio is a predictor of hepatitis B virus related decompensated cirrhosis: time-dependent receiver operating characteristics and decision curve analysis[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2017,29(4):472-480.
APA	Huang, Si-Si., Xie, Dong-Mei., Cai, Yi-Jing., Wu, Jian-Min., Chen, Rui-Chong., ... & Shi, Ke-Qing. (2017). C-reactive protein-to-albumin ratio is a predictor of hepatitis B virus related decompensated cirrhosis: time-dependent receiver operating characteristics and decision curve analysis. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(4), 472-480.
MLA	Huang, Si-Si,et al."C-reactive protein-to-albumin ratio is a predictor of hepatitis B virus related decompensated cirrhosis: time-dependent receiver operating characteristics and decision curve analysis".EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 29.4(2017):472-480.