科研成果详情

题名Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy
作者
发表日期2018-12-31
发表期刊INTERNATIONAL JOURNAL OF NANOMEDICINE   影响因子和分区
语种英语
原始文献类型Article
关键词zinc oxide nanoparticles mitophagy tongue cancer anticancer therapy
其他关键词ZNO NANOPARTICLES ; CARCINOMA ; PARKIN ; MITOCHONDRIA ; APOPTOSIS ; EXPOSURE ; THERAPY ; DAMAGE ; DEATH ; HEAD
摘要Background: Tongue squamous cell carcinoma (tongue cancer) is one of the most common malignancies in the oral maxillofacial region. The tumor easily relapses after surgery, and the prognosis remains poor. Recently, zinc oxide nanoparticles (ZnO NPs) were shown to target multiple cancer cell types. In this study, we aimed to elucidate the anticancer effect of ZnO NPs on CAL 27 human tongue cancer cells and identify the role of PINK1/Parkin-mediated mitophagy in this effect. Materials and methods: We analyzed the dose-dependent cytotoxic effects of ZnO NPs on CAL 27 cells. Cells were cultured in media containing 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, or 100 mu g/mL ZnO NPs for 24 h. We further examined the intracellular reactive oxygen species levels, monodansylcadaverine intensity and mitochondrial membrane potential following the administration of 25 mu g/mL ZnO NPs for 4, 8, 12, or 24 h and investigated the role of PINK1/Parkin-mediated mitophagy in ZnO NP-induced toxicity in CAL 27 cells. Results: The viability of CAL 27 cells decreased after treatment with increasing ZnO NP concentrations. The inhibitory concentration 50% of the ZnO NPs was calculated as 25 mu g/mL. The ZnO NPs increased the intracellular reactive oxygen species levels and decreased the mitochondrial membrane potential in a time-dependent manner as well as activated the PINK1/Parkin-mediated mitophagy process in CAL 27 cells. Conclusion: Based on our findings, ZnO NPs may possess potential anticancer activity toward tongue cancer cells.
资助项目Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY16H140003, LY17H140008]; Wenzhou Municipal Science and Technology Bureau Foundation of China [Y20150070, Y20150256]
出版者DOVE MEDICAL PRESS LTD
出版地ALBANY
ISSN1178-2013
EISSN1178-2013
卷号13页码:3441-3450
DOI10.2147/IJN.S165699
页数10
WOS类目Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS记录号WOS:000435879300001
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID29950828
PMC记录号PMC6016020
SCOPUSEID2-s2.0-85049233767
通讯作者地址[Wei, Limin]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类Biophysics;Bioengineering;Biomaterials;Pharmaceutical Science;Drug Discovery;Organic Chemistry
TOP期刊TOP期刊
引用统计
被引频次:64[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/16181
专题口腔医学院、附属口腔医院
口腔医学院、附属口腔医院_儿童口腔
通讯作者Wei, Limin
作者单位
1.Department of Orthodontics,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China;
2.Department of Nuclear Medicine,Handan Central Hospital,Handan,China;
3.Department of Pediatric Dentistry,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China
第一作者单位口腔医学院、附属口腔医院
通讯作者单位口腔医学院、附属口腔医院
第一作者的第一单位口腔医学院、附属口腔医院
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GB/T 7714
Wang, Jianfeng,Gao, Shutao,Wang, Shuyu,et al. Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:3441-3450.
APA Wang, Jianfeng, Gao, Shutao, Wang, Shuyu, Xu, Zhaonan, & Wei, Limin. (2018). Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy. INTERNATIONAL JOURNAL OF NANOMEDICINE, 13, 3441-3450.
MLA Wang, Jianfeng,et al."Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):3441-3450.

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