Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice

doi:10.1016/j.jhazmat.2016.06.054

科研成果详情

题名	Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice
作者	Chen, Yuanhong1; Hu, Yabing 1; Liu, Shuyun 1; Zheng, Huiying1; Wu, Xiaojuan 1; Huang, Zhengyu 1; Li, Hao 1; Peng, Baoqi1; Long, Jinlie 1; Pan, Bishu 2; Huang, Changjiang 1; Dong, Qiaoxiang1
发表日期	2016-11-15
发表期刊	JOURNAL OF HAZARDOUS MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Tetrabromobisphenol A Cadmium Hepatic toxicity Inhalation toxicity Oxidative stress marker
其他关键词	BROMINATED FLAME RETARDANTS ; SOUTHEAST CHINA ; HEAVY-METALS ; RATS ; GLUTATHIONE ; BIOMARKERS ; DUST ; SITE ; HEXABROMOCYCLODODECANE ; XENOBIOTICS
摘要	Cadmium (Cd) and tetrabromobisphenol A (TBBPA) are two prevalent contaminants in e-waste recycling facilities. However, the potential adversely health effect of co-exposure to these two types of pollutants in an occupational setting is unknown. In this study, we investigated co-exposure of these two pollutants on hepatic toxicity in CD-1 male mice through a whole-body aerosol inhalation route. Specifically, mice were exposed to solvent control (5% DMSO), Cd (8 mu g/m(3)), TBBPA (16 mu g/m(3)) and Cd/TBBPA mixture for 8h/day and 6 days a week for 60 days. Hepatic changes include increased organ weight, focal necrosis, and elevated levels of liver enzymes in serum. These changes were most severe in mice exposed to TBBPA, followed by Cd/TBBPA mixture and Cd. These chemicals also led to suppressed antioxidant defensive mechanisms and increased oxidative stress. Further, these chemicals induced gene expression of apoptosis-related genes, activated genes encoding for phase I detoxification enzymes and inhibited genes encoding for phase II detoxification enzymes. These findings indicate that the hepatic damages induced by subchronic aerosol exposure of Cd and TBBPA may result from the oxidative damages caused by excessive ROS production when these chemicals were metabolized in the liver. (C) 2016 Elsevier B.V. All rights reserved.
资助项目	National Environmental Protection Public Welfare Science and Technology Research Program of China [201309047]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41271491]; key project of Natural Science Foundation of Zhejiang Province [LZ13B070001]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	0304-3894
EISSN	1873-3336
卷号	318 页码:109-116
DOI	10.1016/j.jhazmat.2016.06.054
页数	47
WOS类目	Engineering, Environmental ; Environmental Sciences
WOS研究方向	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:000383003200014
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20162902610430
EI主题词	Cadmium chloride
URL	查看原文
PubMed ID	27415598
SCOPUSEID	2-s2.0-84978035421
通讯作者地址	[Huang, Changjiang]Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Environmental Engineering;Environmental Chemistry;Waste Management and Disposal;Pollution;Health, Toxicology and Mutagenesis
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16025
专题	公共卫生学院_健康与环境生态研究所公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Huang, Changjiang
作者单位	1.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 2.Taizhou Center for Disease Control and Prevention,Taizhou,318000,China
第一作者单位	环境安全与健康风险评估研究院
通讯作者单位	环境安全与健康风险评估研究院
第一作者的第一单位	环境安全与健康风险评估研究院
推荐引用方式 GB/T 7714	Chen, Yuanhong,Hu, Yabing,Liu, Shuyun,et al. Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice[J]. JOURNAL OF HAZARDOUS MATERIALS,2016,318:109-116.
APA	Chen, Yuanhong., Hu, Yabing., Liu, Shuyun., Zheng, Huiying., Wu, Xiaojuan., ... & Dong, Qiaoxiang. (2016). Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice. JOURNAL OF HAZARDOUS MATERIALS, 318, 109-116.
MLA	Chen, Yuanhong,et al."Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice".JOURNAL OF HAZARDOUS MATERIALS 318(2016):109-116.