题名 | Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice |
作者 | |
发表日期 | 2016-11-15 |
发表期刊 | JOURNAL OF HAZARDOUS MATERIALS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Tetrabromobisphenol A Cadmium Hepatic toxicity Inhalation toxicity Oxidative stress marker |
其他关键词 | BROMINATED FLAME RETARDANTS ; SOUTHEAST CHINA ; HEAVY-METALS ; RATS ; GLUTATHIONE ; BIOMARKERS ; DUST ; SITE ; HEXABROMOCYCLODODECANE ; XENOBIOTICS |
摘要 | Cadmium (Cd) and tetrabromobisphenol A (TBBPA) are two prevalent contaminants in e-waste recycling facilities. However, the potential adversely health effect of co-exposure to these two types of pollutants in an occupational setting is unknown. In this study, we investigated co-exposure of these two pollutants on hepatic toxicity in CD-1 male mice through a whole-body aerosol inhalation route. Specifically, mice were exposed to solvent control (5% DMSO), Cd (8 mu g/m(3)), TBBPA (16 mu g/m(3)) and Cd/TBBPA mixture for 8h/day and 6 days a week for 60 days. Hepatic changes include increased organ weight, focal necrosis, and elevated levels of liver enzymes in serum. These changes were most severe in mice exposed to TBBPA, followed by Cd/TBBPA mixture and Cd. These chemicals also led to suppressed antioxidant defensive mechanisms and increased oxidative stress. Further, these chemicals induced gene expression of apoptosis-related genes, activated genes encoding for phase I detoxification enzymes and inhibited genes encoding for phase II detoxification enzymes. These findings indicate that the hepatic damages induced by subchronic aerosol exposure of Cd and TBBPA may result from the oxidative damages caused by excessive ROS production when these chemicals were metabolized in the liver. (C) 2016 Elsevier B.V. All rights reserved. |
资助项目 | National Environmental Protection Public Welfare Science and Technology Research Program of China [201309047]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41271491]; key project of Natural Science Foundation of Zhejiang Province [LZ13B070001] |
出版者 | ELSEVIER SCIENCE BV |
出版地 | AMSTERDAM |
ISSN | 0304-3894 |
EISSN | 1873-3336 |
卷号 | 318页码:109-116 |
DOI | 10.1016/j.jhazmat.2016.06.054 |
页数 | 47 |
WOS类目 | Engineering, Environmental ; Environmental Sciences |
WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
WOS记录号 | WOS:000383003200014 |
收录类别 | SCIE ; PUBMED ; EI ; SCOPUS |
EI入藏号 | 20162902610430 |
EI主题词 | Cadmium chloride |
URL | 查看原文 |
PubMed ID | 27415598 |
SCOPUSEID | 2-s2.0-84978035421 |
通讯作者地址 | [Huang, Changjiang]Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China |
Scopus学科分类 | Environmental Engineering;Environmental Chemistry;Waste Management and Disposal;Pollution;Health, Toxicology and Mutagenesis |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/16025 |
专题 | 公共卫生学院_健康与环境生态研究所 公共卫生学院_环境安全与健康风险评估研究院 |
通讯作者 | Huang, Changjiang |
作者单位 | 1.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 2.Taizhou Center for Disease Control and Prevention,Taizhou,318000,China |
第一作者单位 | 环境安全与健康风险评估研究院 |
通讯作者单位 | 环境安全与健康风险评估研究院 |
第一作者的第一单位 | 环境安全与健康风险评估研究院 |
推荐引用方式 GB/T 7714 | Chen, Yuanhong,Hu, Yabing,Liu, Shuyun,et al. Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice[J]. JOURNAL OF HAZARDOUS MATERIALS,2016,318:109-116. |
APA | Chen, Yuanhong., Hu, Yabing., Liu, Shuyun., Zheng, Huiying., Wu, Xiaojuan., ... & Dong, Qiaoxiang. (2016). Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice. JOURNAL OF HAZARDOUS MATERIALS, 318, 109-116. |
MLA | Chen, Yuanhong,et al."Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice".JOURNAL OF HAZARDOUS MATERIALS 318(2016):109-116. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论