科研成果详情

题名Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice
作者
发表日期2016-11-15
发表期刊JOURNAL OF HAZARDOUS MATERIALS   影响因子和分区
语种英语
原始文献类型Article
关键词Tetrabromobisphenol A Cadmium Hepatic toxicity Inhalation toxicity Oxidative stress marker
其他关键词BROMINATED FLAME RETARDANTS ; SOUTHEAST CHINA ; HEAVY-METALS ; RATS ; GLUTATHIONE ; BIOMARKERS ; DUST ; SITE ; HEXABROMOCYCLODODECANE ; XENOBIOTICS
摘要Cadmium (Cd) and tetrabromobisphenol A (TBBPA) are two prevalent contaminants in e-waste recycling facilities. However, the potential adversely health effect of co-exposure to these two types of pollutants in an occupational setting is unknown. In this study, we investigated co-exposure of these two pollutants on hepatic toxicity in CD-1 male mice through a whole-body aerosol inhalation route. Specifically, mice were exposed to solvent control (5% DMSO), Cd (8 mu g/m(3)), TBBPA (16 mu g/m(3)) and Cd/TBBPA mixture for 8h/day and 6 days a week for 60 days. Hepatic changes include increased organ weight, focal necrosis, and elevated levels of liver enzymes in serum. These changes were most severe in mice exposed to TBBPA, followed by Cd/TBBPA mixture and Cd. These chemicals also led to suppressed antioxidant defensive mechanisms and increased oxidative stress. Further, these chemicals induced gene expression of apoptosis-related genes, activated genes encoding for phase I detoxification enzymes and inhibited genes encoding for phase II detoxification enzymes. These findings indicate that the hepatic damages induced by subchronic aerosol exposure of Cd and TBBPA may result from the oxidative damages caused by excessive ROS production when these chemicals were metabolized in the liver. (C) 2016 Elsevier B.V. All rights reserved.
资助项目National Environmental Protection Public Welfare Science and Technology Research Program of China [201309047]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41271491]; key project of Natural Science Foundation of Zhejiang Province [LZ13B070001]
出版者ELSEVIER SCIENCE BV
出版地AMSTERDAM
ISSN0304-3894
EISSN1873-3336
卷号318页码:109-116
DOI10.1016/j.jhazmat.2016.06.054
页数47
WOS类目Engineering, Environmental ; Environmental Sciences
WOS研究方向Engineering ; Environmental Sciences & Ecology
WOS记录号WOS:000383003200014
收录类别SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号20162902610430
EI主题词Cadmium chloride
URL查看原文
PubMed ID27415598
SCOPUSEID2-s2.0-84978035421
通讯作者地址[Huang, Changjiang]Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类Environmental Engineering;Environmental Chemistry;Waste Management and Disposal;Pollution;Health, Toxicology and Mutagenesis
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/16025
专题公共卫生学院_健康与环境生态研究所
公共卫生学院_环境安全与健康风险评估研究院
通讯作者Huang, Changjiang
作者单位
1.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China;
2.Taizhou Center for Disease Control and Prevention,Taizhou,318000,China
第一作者单位环境安全与健康风险评估研究院
通讯作者单位环境安全与健康风险评估研究院
第一作者的第一单位环境安全与健康风险评估研究院
推荐引用方式
GB/T 7714
Chen, Yuanhong,Hu, Yabing,Liu, Shuyun,et al. Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice[J]. JOURNAL OF HAZARDOUS MATERIALS,2016,318:109-116.
APA Chen, Yuanhong., Hu, Yabing., Liu, Shuyun., Zheng, Huiying., Wu, Xiaojuan., ... & Dong, Qiaoxiang. (2016). Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice. JOURNAL OF HAZARDOUS MATERIALS, 318, 109-116.
MLA Chen, Yuanhong,et al."Whole-body aerosol exposure of cadmium chloride (CdCI2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice".JOURNAL OF HAZARDOUS MATERIALS 318(2016):109-116.

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