Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study

doi:10.3389/fnagi.2020.613498

科研成果详情

题名	Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study
作者	Miao, Hanpei 1; Zhu, Hanyu2; Luan, Xiaoqian2; Huang, Guiqian2; Chen, Meixia 3; Yuan, Zhengzhong4; Wang, Zhen2
发表日期	2021-01-18
发表期刊	FRONTIERS IN AGING NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ischemic stroke vitamin D fibrinogen National Institute of Health Stroke Scale score Chinese
其他关键词	25-HYDROXYVITAMIN D PREDICTS ; INCIDENT STROKE ; GLOBAL BURDEN ; DISEASE ; MORTALITY ; EVENTS
摘要	Purpose: Lower serum vitamin D has been reported to be associated with stroke. This study aimed to analyze the risk factors of vitamin deficiency in Chinese stroke patients, and further analyze its impact in different gender and their clinical variables. Methods: 982 stroke patients were enrolled. Laboratory parameters such as serum vitamin D, apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB), ApoA-I/ApoB, cholesterol (CH), fibrinogen (FIB), blood glucose (Glu), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were collected and recorded. The severity of stroke was assessed by National Institute of Health Stroke Scale (NIHSS) score. Based on their serum vitamin D level, patients were divided into three groups: Vitamin D deficiency (<50 nmol/L), vitamin D insufficiency (>= 50-75 nmol/L) and vitamin D sufficiency (>= 75 nmol/L) and differences were compared among the three groups. Statistical analyses were done to assess the risk factors for serum vitamin D deficiency in our ischemic stroke patients. Results: Gender, NIHSS, and FIB showed significant differences among the vitamin D groups (P < 0.001 similar to P = 0.002). The female gender (OR = 2.422, P < 0.001), severity of stroke using NIHSS (OR = 1.055, P = 0.008) and FIB (OR = 1.256, P = 0.005) were risk factors of vitamin D deficiency in ischemic stroke patients. In subgroup analysis, NIHSS was significantly associated with vitamin D deficiency in the male group (OR = 1.087, P = 0.002) and higher FIB group (OR = 1.078, P = 0.001). Conclusions: The female gender, severity of stroke using NIHSS and FIB were risk factors for vitamin D deficiency in our incident stroke patients. NIHSS was more sensitive to vitamin D deficiency in male ischemic stroke patients. Besides, under higher FIB circumstance, the increasing NIHSS score was more related to the vitamin D deficiency. Levels of vitamin D in patients with ischemic stroke should be well monitored during the disease cascade.
资助项目	National Traditional Chinese Medicine Administration National Traditional Chinese Medicine Experts Inheritance Studio Construction Project [Ministry of Medicine in China] [(2019)41]; Science and Technology Bureau of Taizhou [1902ky172]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-4365
卷号	12 页码:613498
DOI	10.3389/fnagi.2020.613498
页数	8
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:000613339800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33536895
PMC记录号	PMC7849025
SCOPUSEID	2-s2.0-85100530905
通讯作者地址	[Wang, Zhen]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Chen, Meixia]Department of Neurology,The Yuhuan People’s Hospital,Taizhou,China ; [Yuan, Zhengzhong]Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15890
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院_中医科第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Chen, Meixia; Yuan, Zhengzhong; Wang, Zhen
作者单位	1.Department of Ophthalmology,Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Neurology,The Yuhuan People’s Hospital,Taizhou,China; 4.Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Miao, Hanpei,Zhu, Hanyu,Luan, Xiaoqian,et al. Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study[J]. FRONTIERS IN AGING NEUROSCIENCE,2021,12:613498.
APA	Miao, Hanpei., Zhu, Hanyu., Luan, Xiaoqian., Huang, Guiqian., Chen, Meixia., ... & Wang, Zhen. (2021). Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study. FRONTIERS IN AGING NEUROSCIENCE, 12, 613498.
MLA	Miao, Hanpei,et al."Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study".FRONTIERS IN AGING NEUROSCIENCE 12(2021):613498.