Development of a Nomogram for Predicting pelvic lymph node metastasis in cervical squamous cell carcinoma.

doi:10.1002/ijgo.14441

科研成果详情

题名	Development of a Nomogram for Predicting pelvic lymph node metastasis in cervical squamous cell carcinoma.
作者	Yang, Simeng1; Zhao, Jing 1; Zhao, Hongqin1; Hu, Yan1; Zhu, Haiyan 1,2
发表日期	2023-03
发表期刊	International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Cervical squamous cell carcinoma Lymph nodes Metastasis Nomogram model
其他关键词	CANCER ; LYMPHADENECTOMY ; SURVIVAL
摘要	To develop and validate a nomogram for predicting pelvic lymph node metastasis(LNM)in cervical squamous cell carcinoma(SCC)., This was a retrospective study that included 715 patients with cervical SCC who underwent radical hysterectomy and bilateral pelvic lymphadenectomy between 2009 and 2018. Logistic regression analysis was used to identify independent risk factors for pelvic LNM. Based on these risk factors, a nomogram predicting LNM risk was constructed and internally validated using the bootstrapping resampling method., The rate of LNM in FIGO stage IA2-IIA2 cervical SCC was 24.2%. In multivariate analysis, FIGO stage II, moderately differentiated or poorly differentiated histology, abnormally elevated serum SCC-Ag, and triglyceride were identified as independent risk factors for LNM. Tumor size>2 cm and parametrial involvement(PI) have borderline significance. Ultimately, the nomogram contained the six variables mentioned above, showing positive calibration and positive discrimination. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.827 (The C-index was 0.827). The bootstrap-validated C-index was 0.827. And the Youden index of this paper is 0.540., We developed and validated a nomogram to predict pelvic lymph node metastasis in squamous cervical cancer based on clinical data, which can help physicians develop an optimal treatment strategy.
资助项目	Zhejiang medicine and health science and technology project [2019KY100]
出版者	WILEY
出版地	HOBOKEN
ISSN	0020-7292
EISSN	1879-3479
卷号	160 期号:3 页码:1020-1027
DOI	10.1002/ijgo.14441
页数	8
WOS类目	Obstetrics & Gynecology
WOS研究方向	Obstetrics & Gynecology
WOS记录号	WOS:000855969300001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2022-09
URL	查看原文
PubMed ID	36074057
SCOPUSEID	2-s2.0-85138358555
通讯作者地址	[Zhu, Haiyan]Department of Gynecology,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,2699 Gaoke west Road,Shanghai,200126,China
Scopus学科分类	Obstetrics and Gynecology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155563
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院
通讯作者	Zhu, Haiyan
作者单位	1.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Gynecology,Shanghai First Maternity and Infant Hospital,Shanghai,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Simeng,Zhao, Jing,Zhao, Hongqin,et al. Development of a Nomogram for Predicting pelvic lymph node metastasis in cervical squamous cell carcinoma.[J]. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,2023,160(3):1020-1027.
APA	Yang, Simeng, Zhao, Jing, Zhao, Hongqin, Hu, Yan, & Zhu, Haiyan. (2023). Development of a Nomogram for Predicting pelvic lymph node metastasis in cervical squamous cell carcinoma.. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 160(3), 1020-1027.
MLA	Yang, Simeng,et al."Development of a Nomogram for Predicting pelvic lymph node metastasis in cervical squamous cell carcinoma.".International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 160.3(2023):1020-1027.