Roles of the fibroblast growth factor signal transduction system in tissue injury repair

doi:10.1093/burnst/tkac005

科研成果详情

名称	Roles of the fibroblast growth factor signal transduction system in tissue injury repair
作者	Chen, Keyang1,3,4,5; Rao, Zhiheng1,3,4,5; Dong, Siyang1,2; Chen, Yajing1; Wang, Xulan1; Luo, Yongde 1,2,5; Gong, Fanghua1,5; Li, Xiaokun1,5
发表期刊	BURNS & TRAUMA
语种	英语
原始文献类型	Review
关键词	Tissue injury Repair Regeneration Cell growth Fibroblast growth factor Signal transduction
其他关键词	PLACEBO-CONTROLLED TRIAL ; SPINAL-CORD-INJURY ; TYMPANIC MEMBRANE PERFORATIONS ; SKELETAL-MUSCLE REGENERATION ; STEM-CELLS ; FACTOR-I ; INTRAARTICULAR SPRIFERMIN ; MYOCARDIAL-INFARCTION ; FACTOR RECEPTOR-3 ; PI3K-AKT-RAC1 PATHWAY
摘要	Following injury, tissue autonomously initiates a complex repair process, resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors, cytokines and other signaling molecules under normal conditions. However, under chronic traumatic or pathological conditions, the reparative or regenerative process of most tissues in different organs can lose control to different extents, leading to random, incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function, accompanied by the development of fibrosis, scarring or even pathogenesis that could cause organ failure and death of the organism. Ample evidence suggests that the various combinatorial fibroblast growth factor (FGF) and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis. In this review, we attempt to provide a brief update on our current understanding of the roles, the underlying mechanisms and clinical application of FGFs in tissue injury repair.
资助项目	Wenzhou Medical University; First Affiliated Hospital; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2019-I2M-5-028]
出版者	OXFORD UNIV PRESS
出版地	OXFORD
ISSN	2321-3868
EISSN	2321-3876
卷号	10
DOI	10.1093/burnst/tkac005
页数	21
WOS类目	Emergency Medicine ; Dermatology ; Surgery
WOS研究方向	Emergency Medicine ; Dermatology ; Surgery
WOS记录号	WOS:000808362700005
收录类别	SCIE
发布日期	2022
PubMed ID	35350443
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154863
专题	药学院（分析测试中心）附属第一医院第二临床医学院、附属第二医院、育英儿童医院卓越中心_国际生长因子研究院
通讯作者	Luo, Yongde
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Breast Surg, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China; 5.Chinese Acad Med Sci, Wenzhou Med Univ, Res Units Clin Translat Cell Growth Factors & Dis, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	药学院（分析测试中心）; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 神经内科; 神经病学; 国际生长因子研究院
推荐引用方式 GB/T 7714	Chen, Keyang,Rao, Zhiheng,Dong, Siyang,et al. Roles of the fibroblast growth factor signal transduction system in tissue injury repair. 2022.