Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis

doi:10.1007/s43032-022-00856-8

科研成果详情

名称	Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis
作者	Hu, Kai-Lun 1,2; Chen, Zimiao3; Deng, Wenhai 2; Li, Xiaoxue 2; Ju, Liping 2; Yang, Haiyan4; Zhang, Hong 5; Mu, Liangshan 2
发表期刊	REPRODUCTIVE SCIENCES
语种	英语
原始文献类型	Review ; Early Access
关键词	Kisspeptin Miscarriage hCG Systematic review
其他关键词	HUMAN CHORIONIC-GONADOTROPIN ; PROTEIN-COUPLED RECEPTOR ; INVITRO FERTILIZATION ; EMBRYO-TRANSFER ; MISCARRIAGE ; BIOMARKER ; KISS-1 ; GENE
摘要	The objective of this study is to investigate whether kisspeptin levels in early pregnancy have a better diagnostic value on early pregnancy outcome as compared with human chorionic gonadotropin (hCG). This study was a systematic review and meta-analysis aiming to investigate the diagnostic value of kisspeptin levels on early pregnancy outcome. The primary outcome was miscarriage or viable intrauterine pregnancy. Five studies were included for systematic review, and three studies were included for meta-analysis. Meta-analysis showed kisspeptin levels had a good diagnostic value with the area under the curve (AUC) 0.902 (0.866, 0.937) when kisspeptin was measured after 6 weeks of gestation. Sensitivity analysis demonstrated kisspeptin levels had a diagnostic value with AUC = 0.881 (0.855, 0.906). hCG levels had a diagnostic value with AUC = 0.834 (0.785, 0.883), which was inferior to the diagnostic value of kisspeptin (mean difference = 0.09 (0.02, 0.16)). Kisspeptin measurement has a potential for comparable or even higher accuracy than hCG in differentiating between miscarriage and viable intrauterine pregnancy after 6 weeks of gestation.
资助项目	National Natural Science Foundation of China [81873835, 82071726]
出版者	SPRINGER HEIDELBERG
出版地	HEIDELBERG
ISSN	1933-7191
EISSN	1933-7205
DOI	10.1007/s43032-022-00856-8
页数	8
WOS类目	Obstetrics & Gynecology ; Reproductive Biology
WOS研究方向	Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:000761891800004
收录类别	SCIE
发布日期	2022-08-01
PubMed ID	35212930
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154830
专题	附属第一医院_内分泌科第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Peking Univ, Ctr Reprod Med, Hosp 3, 49 Huayuan North Rd, Beijing 100191, Peoples R China; 2.Zhejiang MedicalTech Therapeut Co, 665 Yumeng Rd, Wenzhou 325200, Peoples R China; 3.Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 4.Wenzhou Med Univ, Reprod Med Ctr, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 5.Soochow Univ, Med Reprod Ctr, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215026, Peoples R China
推荐引用方式 GB/T 7714	Hu, Kai-Lun,Chen, Zimiao,Deng, Wenhai,et al. Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis. 2022.