A Clinical Analysis and Literature Review of Six Cases with Primary Pulmonary Lymphoepithelioma-Like Carcinoma

doi:10.1155/2022/1086697

科研成果详情

名称	A Clinical Analysis and Literature Review of Six Cases with Primary Pulmonary Lymphoepithelioma-Like Carcinoma
作者	Ye, Lingyan1; Luo, Dinghai 2; Li, Haiyan 1; Zheng, Haihong 3; He, Susu 1; Lin, Ling 1; Fang, Yicheng4; Ye, Junhui 5; Chen, Chengshui 6
发表期刊	COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
语种	英语
原始文献类型	Review
其他关键词	EPSTEIN-BARR-VIRUS ; COMPUTED-TOMOGRAPHY CHARACTERISTICS ; MULTIMODALITY TREATMENT ; LUNG ; CLASSIFICATION ; FEATURES
摘要	Object. To investigate the clinicopathological features, imaging findings, treatment, and prognosis of primary pulmonary lymphoepitheliomatoid-like carcinoma. Methods. The clinical data of six patients with primary pulmonary lymphoepithelioma-like carcinoma treated in Zhejiang Taizhou Hospital of Taizhou Enze Medical Center (Group) from May 2014 to December 2018 were summarized and analyzed. Combined with the relevant literature, the primary pulmonary lymphoepithelioma-like carcinoma was analyzed retrospectively. Results. The main manifestations of six patients were respiratory symptoms, and cough was the most common. The imaging features of six patients were mainly round-like high-density mass shadow or nodule shadow. All patients were diagnosed by pathology. Microscopically, the cancer cells were nested, with large nuclei and vacuoles and abundant lymphocyte infiltration in the tumor stroma. The positive rates of EBER, p63, CK5/6, and Ki-67 were high, and TTF-1 was negative. Five patients received surgical treatment. One patient developed brain metastasis 12 months after operation and received craniocerebral radiotherapy. The other patients did not receive radiotherapy and chemotherapy, and one patient did not receive treatment. After follow-up, four patients survived so far, the longest survival time was 82 months, one patient lost follow-up, and one patient died of lung metastasis 24 months after operation. Conclusion. Primary pulmonary lymphoepitheliomatoid-like carcinoma is a rare lung malignant tumor, whose pathogenesis is related to Epstein-Barr virus infection. The clinical manifestations are nonspecific, but with unique pathological characteristics. Surgical resection is the proper treatment for early-stage patients, and comprehensive treatment with surgery as the main treatment is suitable for late-stage patients. The prognosis is good.
资助项目	Medical Science and Technology Project Foundation of Zhejiang Province of China [2021KY1202]; Scientific Research Foundation of Taizhou Enze Medical Center (Group) [20EZZDB1]; Scientific Research Fund of Taizhou Science and Technology Agency [1801ky68, 21ywa24]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1748-670X
EISSN	1748-6718
卷号	2022
DOI	10.1155/2022/1086697
页数	6
WOS类目	Mathematical & Computational Biology
WOS研究方向	Mathematical & Computational Biology
WOS记录号	WOS:000796887100002
收录类别	SCIE
发布日期	2022-04-29
PubMed ID	35529269
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154757
专题	其他_附属台州医院（浙江省台州医院）基础医学院（机能实验教学中心）_病理学与病理生理学系第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科
通讯作者	Ye, Junhui
作者单位	1.Wenzhou Med Univ, Dept Resp Med, Taizhou Hosp Zhejiang Prov, Linhai, Peoples R China; 2.Wenzhou Med Univ, Dept Gastroenterol, Taizhou Hosp Zhejiang Prov, Taizhou, Peoples R China; 3.Wenzhou Med Univ, Dept Pathol, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Dept Radiol, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China; 5.Peoples Hosp Sanmen, Dept Resp Med, Taizhou, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Dept Resp & Crit Care Med, First Affiliated Hosp, Wenzhou, Zhejiang, Peoples R China
第一作者单位	其他_附属台州医院（浙江省台州医院）
推荐引用方式 GB/T 7714	Ye, Lingyan,Luo, Dinghai,Li, Haiyan,et al. A Clinical Analysis and Literature Review of Six Cases with Primary Pulmonary Lymphoepithelioma-Like Carcinoma. 2022.