Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis

doi:10.1080/10408398.2022.2077693

科研成果详情

名称	Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis
作者	Shi, Jiangmin1; Wang, Qinjian1; Ruan, Gaoyi1; Chen, Yaoxuan1; Zhao, Min1; Shi, Dibang1; Pan, Binhui 1; Xu, Zhihua 1; Zhang, Tiaotiao1; Wang, Fangyan2; Xu, Changlong1
发表期刊	CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
语种	英语
原始文献类型	Review ; Early Access
关键词	Dental caries probiotics children Streptococcus mutans Lactobacillus meta-analysis
其他关键词	SALIVARY MUTANS-STREPTOCOCCI ; LACTOBACILLUS-PARACASEI SD1 ; DOUBLE-BLIND ; ORAL-HEALTH ; BIFIDOBACTERIUM-LACTIS ; EARLY-CHILDHOOD ; ICE-CREAM ; PRESCHOOL-CHILDREN ; ACID PRODUCTION ; RISK-FACTORS
摘要	Dental caries causes serious consequences and the financial burden of society especially in children with high morbidity rate. Here we carried out a meta-analysis to systematically evaluate the efficacy of probiotics against dental caries in children. Forty-three RCTs were eligible for this meta-analysis after searching the PubMed, Cochrane and Web of Science from the inception through October 2021. Pooled estimates demonstrated that treatment with probiotics significantly reduced noncavitated (dicdas2-6mft) (SMD = -0.18, 95% CI: -0.3 to -0.06, p = 0.002) and cavitated (dicdas5-6mft) carious lesions in children (SMD = -0.32, 95% CI: -0.5 to 0.14, p = 0.0004). Probiotics also reduced prevalence of noncavitated (dicdas2-6mft) carious lesions (RR = 0.8, 95% CI: 0.67 to-0.97, p = 0.02). Salivary Streptococcus mutans was declined after intervention (SMD = -1.17, 95% CI: -1.85 to -0.5, p = 0.0007), while Lactobacillus counts were upregulated (SMD = 1.19, 95% CI: 0.46-1.92, p = 0.001). However, no significant effects in total bacteria counts and salivary pH were observed. Our findings suggest that probiotics especially Lactobacillus could be a promising therapeutic strategy for clinical applications in children dental caries.
资助项目	Natural Science Foundation of Zhejiang Province [LY20H180010]; Wenzhou Municipal Science and Technology Bureau (WMSTB) [Y20180142]
出版者	TAYLOR & FRANCIS INC
出版地	PHILADELPHIA
ISSN	1040-8398
EISSN	1549-7852
DOI	10.1080/10408398.2022.2077693
页数	18
WOS类目	Food Science & Technology ; Nutrition & Dietetics
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000799825900001
收录类别	SCIE
发布日期	2022-08-01
PubMed ID	35607893
TOP期刊	TOP期刊
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154731
专题	第二临床医学院，附属第二医院、育英儿童医院_内科学_消化内科基础医学院（机能实验教学中心）_病理学与病理生理学系
通讯作者	Xu, Changlong
作者单位	1.Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp & Yuying Childrens Hosp 2, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Wenzhou, Peoples R China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_内科学_消化内科
推荐引用方式 GB/T 7714	Shi, Jiangmin,Wang, Qinjian,Ruan, Gaoyi,et al. Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis. 2022.