Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction

doi:10.1186/s12958-022-00953-y

科研成果详情

名称	Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction
作者	Hu, Kai-Lun 1,2; Chen, Zimiao3; Li, Xiaoxue 2; Cai, Enci 4; Yang, Haiyan5; Chen, Yi 5; Wang, Congying 5; Ju, Liping 2; Deng, Wenhai6; Mu, Liangshan 2
发表期刊	REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
语种	英语
原始文献类型	Review
关键词	Kisspeptin KISS1R Hypothalamus Hypothalamic-pituitary-ovarian axis Female reproduction
其他关键词	GONADOTROPIN-RELEASING-HORMONE ; OVARIAN HYPERSTIMULATION SYNDROME ; CENTRAL PRECOCIOUS PUBERTY ; PROTEIN-COUPLED RECEPTOR ; KISS1 GENE-EXPRESSION ; MONKEY MACACA-MULATTA ; CONGENITAL HYPOGONADOTROPIC HYPOGONADISM ; POSITIVE FEEDBACK ACTION ; NEUROKININ B ; ARCUATE NUCLEUS
摘要	Background Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis. Main text Exogenous kisspeptin or its receptor agonist can stimulate GnRH release and subsequent physiological gonadotropin secretion in humans. Based on the role of kisspeptin in the hypothalamus, a broad application of kisspeptin and its receptor agonist has been recently uncovered in humans, including central control of ovulation, oocyte maturation (particularly in women at a high risk of ovarian hyperstimulation syndrome), test for GnRH neuronal function, and gatekeepers of puberty onset. In addition, the kisspeptin analogs, such as TAK-448, showed promising agonistic activity in healthy women as well as in women with hypothalamic amenorrhoea or polycystic ovary syndrome. Conclusion More clinical trials should focus on the therapeutic effect of kisspeptin, its receptor agonist and antagonist in women with reproductive disorders, such as hypothalamic amenorrhoea, polycystic ovary syndrome, and endometriosis.
出版者	BMC
出版地	LONDON
EISSN	1477-7827
卷号	20
期号	1
DOI	10.1186/s12958-022-00953-y
页数	20
WOS类目	Endocrinology & Metabolism ; Reproductive Biology
WOS研究方向	Endocrinology & Metabolism ; Reproductive Biology
WOS记录号	WOS:000799240500001
收录类别	SCIE
发布日期	2022-05-23
PubMed ID	35606759
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154718
专题	附属第一医院_内分泌科检验医学院（生命科学学院、生物学实验教学中心）第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Peking Univ Third Hosp, Ctr Reprod Med, 49 Huayuan North Rd, Beijing 100191, Peoples R China; 2.Zhejiang Med Tech Therapeut Co, 665 Yumeng Rd, Wenzhou 325200, Peoples R China; 3.Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 4.Univ Minnesota Twin Cities, Dept Nutr & Food Sci, Coll Food Agr & Nat Resource Sci, Minneapolis, MN 55455 USA; 5.Wenzhou Med Univ, Reprod Med Ctr, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 6.Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Lab Med, Minist Educ, Wenzhou 325006, Peoples R China
推荐引用方式 GB/T 7714	Hu, Kai-Lun,Chen, Zimiao,Li, Xiaoxue,et al. Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction. 2022.