Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma

doi:10.1186/s12935-022-02643-6

科研成果详情

名称	Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma
作者	He, Qikuan1,2; Guo, Pengyi 3; Bo, Zhiyuan1,2; Yu, Haitao1,2; Yang, Jinhuan1,2; Wang, Yi4; Chen, Gang 1,2
发表期刊	CANCER CELL INTERNATIONAL
语种	英语
原始文献类型	Review
关键词	HCC Chemoresistance CSCs EMT Autophagy EVs Immune surveillance Ferroptosis ncRNAs
其他关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; CELL-PROLIFERATION ; DRUG-RESISTANCE ; T-CELLS ; SORAFENIB RESISTANCE ; POOR-PROGNOSIS ; UP-REGULATION ; SELF-RENEWAL ; STEM-CELLS ; AUTOPHAGY
摘要	Despite the significant progress in decreasing the occurrence and mortality of hepatocellular carcinoma (HCC), it remains a public health issue worldwide on the basis of its late presentation and tumor recurrence. To date, apart from surgical interventions, such as surgical resection, liver transplantation and locoregional ablation, current standard antitumor protocols include conventional cytotoxic chemotherapy. However, due to the high chemoresistance nature, most current therapeutic agents show dismal outcomes for this refractory malignancy, leading to disease relapse. Nevertheless, the molecular mechanisms involved in chemotherapy resistance remain systematically ambiguous. Herein, HCC is hierarchically characterized by the formation of primitive cancer stem cells (CSCs), progression of epithelial-mesenchymal transition (EMT), unbalanced autophagy, delivery of extracellular vesicles (EVs), escape of immune surveillance, disruption of ferroptosis, alteration of the tumor microenvironment and multidrug resistance-related signaling pathways that mediate the multiplicity and complexity of chemoresistance. Of note, anecdotal evidence has corroborated that noncoding RNAs (ncRNAs) extensively participate in the critical physiological processes mentioned above. Therefore, understanding the detailed regulatory bases that underlie ncRNA-mediated chemoresistance is expected to yield novel insights into HCC treatment. In the present review, a comprehensive summary of the latest progress in the investigation of chemotherapy resistance concerning ncRNAs will be elucidated to promote tailored individual treatment for HCC patients.
资助项目	National Natural Science Foundation of China [82072685]
出版者	BMC
出版地	LONDON
EISSN	1475-2867
卷号	22
期号	1
DOI	10.1186/s12935-022-02643-6
页数	17
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000838086500003
收录类别	SCIE
发布日期	2022-08-09
PubMed ID	35945536
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154616
专题	附属第一医院_肝胆外科第一临床医学院（信息与工程学院）、附属第一医院_流行病学第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Chen, Gang
作者单位	1.Wenzhou Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; 3.Ningbo Yinzhou 2 Hosp, Dept Cardiothorac Surg, Ningbo 315199, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Biostat, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	肝胆外科; 浙江省胰脏肝脏危重性疾病重点实验室
推荐引用方式 GB/T 7714	He, Qikuan,Guo, Pengyi,Bo, Zhiyuan,et al. Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma. 2022.