题名 | Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis |
作者 | |
发表日期 | 2022-04-18 |
发表期刊 | FRONTIERS IN NEUROLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | thrombectomy stroke myxoma large vessel occlusion intravenous thrombolysis endovascular therapy |
其他关键词 | NEUROLOGICAL MANIFESTATIONS ; EMBOLIZATION ; EXPERIENCE ; TRIAL |
摘要 | Background and PurposeAcute ischemic stroke (AIS) is a common and life-threatening complication of patients with cardiac myxoma (CM). The role of the mechanical thrombectomy (MT) technique in CM-AIS patients remains unclear, and no guidelines exist for this population. Therefore, we conducted a case series study of MT in CM-AIS patients to investigate its safety and efficacy via a pooled analysis of published literature. MethodsEleven CM-AIS patients who underwent MT between 2016 and 2021 were screened from multicenter stroke databases. Clinical, procedural, and outcome data were obtained from medical records. A systematic review was conducted to identify additional cases from published studies by searching PubMed and China National Knowledge Infrastructure databases. We then performed a pooled analysis of the published cases. ResultsIn the case series study, most patients were male (81.8%), with a median age of 51 years. All patients had CM located in the left atrium. The rate of successful reperfusion using the first-line thrombectomy technique was 100% with stent retriever (SR) and 66.7% with direct aspiration (DA), which resulted in overall successful reperfusion in 94.1% of all occlusions. The retrieved emboli of the five patients who underwent histopathology examination were identified as myxoma components. Hemorrhagic transformation was observed in five (45.5%) patients, of whom one was symptomatic (9.1%). Three-month favorable functional outcomes were achieved in five (45.5%) patients with a 3-month mortality rate of 18.2%. For the literature review, 35 cases with 51 target vessel occlusions were identified and included in the pooled analysis. The rate of successful reperfusion following first-line thrombectomy did not differ between SR (30 patients, 90.9%) and DA (10 patients, 83.3%). The overall successful reperfusion rate was 91.8% of all occlusions. Three-month favorable functional outcomes were achieved in 21 (60.0%) patients, and the mortality rate was 8.6%. ConclusionsOur findings suggest that MT is not only an effective technique but also a safe option for CM-AIS patients with large vessel occlusion. MT has several advantages for this population, which include a high recanalization rate, low bleeding risk, and the ability to evaluate the source of emboli and the etiology of stroke. |
资助项目 | Medical Science and Technology Project of Zhejiang Province of China [2021KY797, 2022KY454]; Wenzhou Basic Scientific Research Project [Y20210900] |
出版者 | FRONTIERS MEDIA SA |
出版地 | LAUSANNE |
ISSN | 1664-2295 |
卷号 | 13页码:877056 |
DOI | 10.3389/fneur.2022.877056 |
页数 | 13 |
WOS类目 | Clinical Neurology ; Neurosciences |
WOS研究方向 | Neurosciences & Neurology |
WOS记录号 | WOS:000810262600001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 35509996 |
SCOPUSEID | 2-s2.0-85129125972 |
通讯作者地址 | [Fu, Fangwang]Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China ; [Cai, Xueli]Department of Neurology,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China |
Scopus学科分类 | Neurology;Neurology (clinical) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/154544 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 附属第一医院_康复科 其他_附属乐清医院(乐清市人民医院) 其他_附属第五医院(丽水市中心医院) 其他_附属黄岩医院(台州市第一人民医院) |
通讯作者 | Cai, Xueli; Fu, Fangwang |
作者单位 | 1.Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China; 3.Department of Neurology,Affiliated Yueqing Hospital,Wenzhou Medical University,Wenzhou,China; 4.Department of Neurology,Ningbo Second Hospital,Ningbo,China; 5.Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Neurology,Huangyan Hospital,Wenzhou Medical University,Taizhou,China; 7.Department of Neurosurgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 第二临床医学院,附属第二医院、育英儿童医院; 附属第二医院; 附属第五医院(丽水市中心医院) |
通讯作者单位 | 第二临床医学院,附属第二医院、育英儿童医院; 附属第二医院; 附属第五医院(丽水市中心医院) |
第一作者的第一单位 | 第二临床医学院,附属第二医院、育英儿童医院 |
推荐引用方式 GB/T 7714 | Rao, Jie,Tao, Zi,Bao, Qiongqiong,et al. Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis[J]. FRONTIERS IN NEUROLOGY,2022,13:877056. |
APA | Rao, Jie., Tao, Zi., Bao, Qiongqiong., Xu, Mengbei., Jiang, Mingxia., ... & Fu, Fangwang. (2022). Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis. FRONTIERS IN NEUROLOGY, 13, 877056. |
MLA | Rao, Jie,et al."Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis".FRONTIERS IN NEUROLOGY 13(2022):877056. |
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