Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis

doi:10.3389/fneur.2022.877056

科研成果详情

题名	Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis
作者	Rao, Jie 1,2; Tao, Zi 1; Bao, Qiongqiong3; Xu, Mengbei 4; Jiang, Mingxia 5; Weng, Xiongpeng 6; Yin, Bo7; Li, Dandong7; Li, Yan1; Cai, Xueli 2; Fu, Fangwang1
发表日期	2022-04-18
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	thrombectomy stroke myxoma large vessel occlusion intravenous thrombolysis endovascular therapy
其他关键词	NEUROLOGICAL MANIFESTATIONS ; EMBOLIZATION ; EXPERIENCE ; TRIAL
摘要	Background and PurposeAcute ischemic stroke (AIS) is a common and life-threatening complication of patients with cardiac myxoma (CM). The role of the mechanical thrombectomy (MT) technique in CM-AIS patients remains unclear, and no guidelines exist for this population. Therefore, we conducted a case series study of MT in CM-AIS patients to investigate its safety and efficacy via a pooled analysis of published literature. MethodsEleven CM-AIS patients who underwent MT between 2016 and 2021 were screened from multicenter stroke databases. Clinical, procedural, and outcome data were obtained from medical records. A systematic review was conducted to identify additional cases from published studies by searching PubMed and China National Knowledge Infrastructure databases. We then performed a pooled analysis of the published cases. ResultsIn the case series study, most patients were male (81.8%), with a median age of 51 years. All patients had CM located in the left atrium. The rate of successful reperfusion using the first-line thrombectomy technique was 100% with stent retriever (SR) and 66.7% with direct aspiration (DA), which resulted in overall successful reperfusion in 94.1% of all occlusions. The retrieved emboli of the five patients who underwent histopathology examination were identified as myxoma components. Hemorrhagic transformation was observed in five (45.5%) patients, of whom one was symptomatic (9.1%). Three-month favorable functional outcomes were achieved in five (45.5%) patients with a 3-month mortality rate of 18.2%. For the literature review, 35 cases with 51 target vessel occlusions were identified and included in the pooled analysis. The rate of successful reperfusion following first-line thrombectomy did not differ between SR (30 patients, 90.9%) and DA (10 patients, 83.3%). The overall successful reperfusion rate was 91.8% of all occlusions. Three-month favorable functional outcomes were achieved in 21 (60.0%) patients, and the mortality rate was 8.6%. ConclusionsOur findings suggest that MT is not only an effective technique but also a safe option for CM-AIS patients with large vessel occlusion. MT has several advantages for this population, which include a high recanalization rate, low bleeding risk, and the ability to evaluate the source of emboli and the etiology of stroke.
资助项目	Medical Science and Technology Project of Zhejiang Province of China [2021KY797, 2022KY454]; Wenzhou Basic Scientific Research Project [Y20210900]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2295
卷号	13 页码:877056
DOI	10.3389/fneur.2022.877056
页数	13
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000810262600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35509996
SCOPUSEID	2-s2.0-85129125972
通讯作者地址	[Fu, Fangwang]Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China ; [Cai, Xueli]Department of Neurology,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154544
专题	第二临床医学院、附属第二医院、育英儿童医院附属第一医院_康复科其他_附属乐清医院（乐清市人民医院）其他_附属第五医院（丽水市中心医院）其他_附属黄岩医院（台州市第一人民医院）
通讯作者	Cai, Xueli; Fu, Fangwang
作者单位	1.Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China; 3.Department of Neurology,Affiliated Yueqing Hospital,Wenzhou Medical University,Wenzhou,China; 4.Department of Neurology,Ningbo Second Hospital,Ningbo,China; 5.Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Neurology,Huangyan Hospital,Wenzhou Medical University,Taizhou,China; 7.Department of Neurosurgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 附属第五医院（丽水市中心医院）
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 附属第五医院（丽水市中心医院）
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Rao, Jie,Tao, Zi,Bao, Qiongqiong,et al. Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis[J]. FRONTIERS IN NEUROLOGY,2022,13:877056.
APA	Rao, Jie., Tao, Zi., Bao, Qiongqiong., Xu, Mengbei., Jiang, Mingxia., ... & Fu, Fangwang. (2022). Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis. FRONTIERS IN NEUROLOGY, 13, 877056.
MLA	Rao, Jie,et al."Mechanical Thrombectomy for Acute Ischemic Stroke in Patients With Cardiac Myxoma: A Case Series and Pooled Analysis".FRONTIERS IN NEUROLOGY 13(2022):877056.