Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia

doi:10.3389/fonc.2022.898236

科研成果详情

题名	Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia
作者	Pan, Jingjing 1; Jiang, Yinyan2; Li, Changhong 1; Jin, Ting3; Yu, Kang2; Jin, Zhenlin2
发表日期	2022-06-10
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	acute myeloid leukemia pyroptosis molecular subtype tumor microenvironment prognosis therapeutic sensitivity
其他关键词	GENE-EXPRESSION ; BREAST-CANCER ; STEM-CELLS ; T-CELLS ; IDENTIFICATION ; DISCOVERY ; SURVIVAL
摘要	Acute myeloid leukemia (AML) is usually associated with poor prognosis and low complete remission (CR) rate due to individual biological heterogeneity. Pyroptosis is a special form of inflammatory programmed cell death related to the progression, treatment response, and prognosis of multiple tumors. However, the potential connection of pyroptosis-related genes (PRGs) and AML still remains unclear. We described the genetic and transcriptional alterations of PRGs in 151 AML samples and presented a consensus clustering of these patients into two subtypes with distinct immunological and prognostic characteristics. Cluster A, associated with better prognosis, was characterized by relatively lower PRG expression, activated immune cells, higher immune scores in the tumor microenvironment (TME), and downregulation of immunotherapy checkpoints. Subsequently, a PRG score was constructed to predict overall survival (OS) of AML patients by using univariate and multivariate Cox regression analysis, and its immunological characteristics and predictive capability were further validated by 1,054 AML samples in external datasets. Besides an immune-activated status, low-PRG score cohorts exhibited higher chemotherapeutic drug sensitivity and significant positive correlation with the cancer stem cell (CSC) index. Combined with age, clinical French-American-British (FAB) subtypes, and PRG score, we successfully constructed a nomogram to effectively predict the 1-/3-/5-year survival rate of AML patients, and the predictive capability was further validated in multiple external datasets with a high area under the curve (AUC) value. The various transcriptomic analysis helps us screen significant pyroptosis-related signatures of AML and provide a new clinical application of PRG scores in predicting the prognosis and benefits of treatment for AML patients.
资助项目	General Scientific Projects of Zhejiang Education Department [Y202147905]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2234-943X
卷号	12 页码:898236
DOI	10.3389/fonc.2022.898236
页数	17
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000815786800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35756629
SCOPUSEID	2-s2.0-85133463814
通讯作者地址	[Yu, Kang]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Jin, Zhenlin]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154529
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_血液内科
通讯作者	Yu, Kang; Jin, Zhenlin
作者单位	1.Department of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Operating Room,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Pan, Jingjing,Jiang, Yinyan,Li, Changhong,et al. Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia[J]. FRONTIERS IN ONCOLOGY,2022,12:898236.
APA	Pan, Jingjing, Jiang, Yinyan, Li, Changhong, Jin, Ting, Yu, Kang, & Jin, Zhenlin. (2022). Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 12, 898236.
MLA	Pan, Jingjing,et al."Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia".FRONTIERS IN ONCOLOGY 12(2022):898236.