题名 | Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia |
作者 | |
发表日期 | 2022-06-10 |
发表期刊 | FRONTIERS IN ONCOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | acute myeloid leukemia pyroptosis molecular subtype tumor microenvironment prognosis therapeutic sensitivity |
其他关键词 | GENE-EXPRESSION ; BREAST-CANCER ; STEM-CELLS ; T-CELLS ; IDENTIFICATION ; DISCOVERY ; SURVIVAL |
摘要 | Acute myeloid leukemia (AML) is usually associated with poor prognosis and low complete remission (CR) rate due to individual biological heterogeneity. Pyroptosis is a special form of inflammatory programmed cell death related to the progression, treatment response, and prognosis of multiple tumors. However, the potential connection of pyroptosis-related genes (PRGs) and AML still remains unclear. We described the genetic and transcriptional alterations of PRGs in 151 AML samples and presented a consensus clustering of these patients into two subtypes with distinct immunological and prognostic characteristics. Cluster A, associated with better prognosis, was characterized by relatively lower PRG expression, activated immune cells, higher immune scores in the tumor microenvironment (TME), and downregulation of immunotherapy checkpoints. Subsequently, a PRG score was constructed to predict overall survival (OS) of AML patients by using univariate and multivariate Cox regression analysis, and its immunological characteristics and predictive capability were further validated by 1,054 AML samples in external datasets. Besides an immune-activated status, low-PRG score cohorts exhibited higher chemotherapeutic drug sensitivity and significant positive correlation with the cancer stem cell (CSC) index. Combined with age, clinical French-American-British (FAB) subtypes, and PRG score, we successfully constructed a nomogram to effectively predict the 1-/3-/5-year survival rate of AML patients, and the predictive capability was further validated in multiple external datasets with a high area under the curve (AUC) value. The various transcriptomic analysis helps us screen significant pyroptosis-related signatures of AML and provide a new clinical application of PRG scores in predicting the prognosis and benefits of treatment for AML patients. |
资助项目 | General Scientific Projects of Zhejiang Education Department [Y202147905] |
出版者 | FRONTIERS MEDIA SA |
出版地 | LAUSANNE |
ISSN | 2234-943X |
卷号 | 12页码:898236 |
DOI | 10.3389/fonc.2022.898236 |
页数 | 17 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000815786800001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 35756629 |
SCOPUSEID | 2-s2.0-85133463814 |
通讯作者地址 | [Yu, Kang]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Jin, Zhenlin]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
Scopus学科分类 | Oncology;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/154529 |
专题 | 检验医学院(生命科学学院、生物学实验教学中心) 附属第一医院_血液内科 |
通讯作者 | Yu, Kang; Jin, Zhenlin |
作者单位 | 1.Department of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Operating Room,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Pan, Jingjing,Jiang, Yinyan,Li, Changhong,et al. Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia[J]. FRONTIERS IN ONCOLOGY,2022,12:898236. |
APA | Pan, Jingjing, Jiang, Yinyan, Li, Changhong, Jin, Ting, Yu, Kang, & Jin, Zhenlin. (2022). Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 12, 898236. |
MLA | Pan, Jingjing,et al."Characteristics of Pyroptosis-Related Subtypes and Novel Scoring Tool for the Prognosis and Chemotherapy Response in Acute Myeloid Leukemia".FRONTIERS IN ONCOLOGY 12(2022):898236. |
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